Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ro 5-3335 is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). It represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. It also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.
Description | Ro 5-3335 is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). It represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. It also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro. |
Targets&IC50 | CBF:1.1 μM |
Synonyms | CBFβ-Runx1 inhibitor II, Ro 5-3335 |
Molecular Weight | 259.69 |
Formula | C13H10ClN3O |
CAS No. | 30195-30-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 100 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Ro5-3335 30195-30-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis Ro53335 CBFβ inhibit binding Ro-5-3335 CBFβ-Runx1 inhibitor II core Ro 5-3335 RUNX1 RUNX1-CBFB factor CBF interaction leukemia Inhibitor Ro5 3335 inhibitor