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Ro5-3335

Catalog No. T4687 CAS 30195-30-3

Synonyms: CBFβ-Runx1 inhibitor II, Ro 5-3335

Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ro5-3335, CAS 30195-30-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 97.00
10 mg	In stock	$ 157.00
25 mg	In stock	$ 319.00
50 mg	In stock	$ 557.00
100 mg	In stock	$ 649.00

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Purity: 99.95%

Purity: 99.42%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

CBF:1.1 μM

Synonyms	CBFβ-Runx1 inhibitor II, Ro 5-3335
Molecular Weight	259.69
Formula	C13H10ClN3O
CAS No.	30195-30-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mM

References and Literature

1. Cunningham L, et al.Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7. 2. Cupelli LA, Hsu MC.The human immunodeficiency virus type 1 Tat antagonist, Ro 5-3335, predominantly inhibits transcription initiation from the viral promoter.J Virol. 1995 Apr;69(4):2640-3. 3. Okuda T,RUNX1/AML1: a central player in hematopoiesis.Int J Hematol. 2001 Oct;74(3):252-7. 4. Wang Y, Wang Q, Wang B, et al. Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells[J]. Cell death & disease. 2020, 11(11): 1-13.

Citations

1. Lin W, Wan X, Sun A, et al. RUNX1/EGFR Pathway Contributes to STAT3 Activation and Tumor Growth Caused by Hyperactivated mTORC1. Molecular Therapy-Oncolytics. 2021 2. Wang Y, Wang Q, Wang B, et al. Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells. Cell death & disease. 2020, 11(11): 1-13. 3. Wu Y, Hu S S, Zhang R, et al.Single cell RNA sequencing unravels mechanisms underlying senescence-like phenotypes of Alveolar Macrophages.iScience.2023 4. Cui X, Huo D, Wang Q, et al.RUNX1/NPM1/H3K4me3 complex contributes to extracellular matrix remodeling via enhancing FOSL2 transcriptional activation in glioblastoma.Cell Death & Disease.2024, 15(1): 98.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Aging Compound Library Preclinical Compound Library Hematonosis Compound Library Anti-Cancer Compound Library Anti-Viral Compound Library Bioactive Compounds Library Max Anti-Infection Compound Library Transcription Factor-Targeted Compound Library ReFRAME Related Library

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Keywords

Ro5-3335 30195-30-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis CBFb-Runx1 inhibitor II Ro53335 CBFβ CBFβ-Runx1 inhibitor II inhibit Ro 5-3335 binding CBFbeta-Runx1 inhibitor II Ro-5-3335 core RUNX1 RUNX1-CBFB factor CBF interaction leukemia Inhibitor Ro5 3335 inhibitor

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