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Ro5-3335

Ro5-3335
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Purity:99.95%
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Ro5-3335

Catalog No. T4687Cas No. 30195-30-3
Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.
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Pack SizePriceAvailabilityQuantity
1 mg$42In Stock
5 mg$97In Stock
10 mg$139In Stock
25 mg$272In Stock
50 mg$455In Stock
100 mg$596In Stock
1 mL x 10 mM (in DMSO)$96In Stock
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Product Introduction

Bioactivity
Description
Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.
AliasCBFβ-Runx1 inhibitor II, Ro 5-3335
Chemical Properties
Molecular Weight259.69
FormulaC13H10ClN3O
Cas No.30195-30-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 60 mg/mL (231.04 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8507 mL19.2537 mL38.5075 mL192.5373 mL
5 mM0.7701 mL3.8507 mL7.7015 mL38.5075 mL
10 mM0.3851 mL1.9254 mL3.8507 mL19.2537 mL
20 mM0.1925 mL0.9627 mL1.9254 mL9.6269 mL
50 mM0.0770 mL0.3851 mL0.7701 mL3.8507 mL
100 mM0.0385 mL0.1925 mL0.3851 mL1.9254 mL

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