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2'-Deoxy-2'-fluorocytidine

Catalog No. T38238 CAS 10212-20-1

2'-Deoxy-2'-fluorocytidine is an nucleoside analog and inhibits of Crimean-Congo hemorrhagic fever virus (CCHFV) replication potently.

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2'-Deoxy-2'-fluorocytidine, CAS 10212-20-1

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	2'-Deoxy-2'-fluorocytidine is an nucleoside analog and inhibits of Crimean-Congo hemorrhagic fever virus (CCHFV) replication potently.
Targets&IC50	CCFHV:61 ± 18 nM(EC50)
In vitro	2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells[1].

Molecular Weight	245.21
Formula	C9H12FN3O4
CAS No.	10212-20-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 5 mg/mL (20.39 mM), ultrasonic and warming and heat to 60°C

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.

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Keywords

2'-Deoxy-2'-fluorocytidine 10212-20-1 DNA损伤和修复微生物学细胞周期 Influenza Virus Nucleoside Antimetabolite/Analog Crimean-Congo hemorrhagic fever 2' Deoxy 2' fluorocytidine Inhibitor nucleoside analog inhibit 2'Deoxy2'fluorocytidine Antiviral,CCHFV inhibitor

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