Powder: -20°C for 3 years
In solvent: -80°C for 2 years
SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
Description | SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element. |
In vitro | SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors in COS-1 cells[2]. |
In vivo | In Sprague-Dawley rats, SR11237 (BMS-649) (25 mg/kg; i.p.) Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis[3]. |
Synonyms | SR 11237 |
Molecular Weight | 380.48 |
Formula | C24H28O4 |
CAS No. | 146670-40-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ethanol: <1 mg/mL
DMSO: 4 mg/mL (10.51 mM), ultrasonic and warming and heat to 60°C
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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SR11237 146670-40-8 代谢 其他 Others RAR/RXR Retinoid X receptors bone BMS 649 transactivate BMS649 Retinoic acid receptors reporter ossification RAR/RXR inhibit Inhibitor RXR/RXR BMS-649 homodimers gene SR 11237 SR-11237 inhibitor