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SR11237

Catalog No. T23383   CAS 146670-40-8
Synonyms: SR 11237

SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.

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SR11237 Chemical Structure
SR11237, CAS 146670-40-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 77.00
5 mg In stock $ 189.00
10 mg In stock $ 287.00
25 mg In stock $ 578.00
50 mg In stock $ 833.00
100 mg In stock $ 1,150.00
500 mg In stock $ 2,290.00
1 mL * 10 mM (in DMSO) In stock $ 239.00
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Purity: 98.54%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
In vitro SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors in COS-1 cells[2].
In vivo In Sprague-Dawley rats, SR11237 (BMS-649) (25 mg/kg; i.p.) Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis[3].
Synonyms SR 11237
Molecular Weight 380.48
Formula C24H28O4
CAS No. 146670-40-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 4 mg/mL (10.51 mM), ultrasonic and warming and heat to 60°C

TargetMolReferences and Literature

1. H.L. Dupuis. The RXR agonist SR-11237 affects skeletal development. ABSTRACT ONLY| VOLUME 24, SUPPLEMENT 1, S147, APRIL 01, 2016. 2. Gendimenico GJ, et al. A pleiotropic response is induced in F9 embryonal carcinoma cells and rhino mouse skin by All-trans-retinoic acid, a RAR agonist but not by SR11237, a RXR-selective agonist. J Invest Dermatol. 1994;102(5):676-680. 3. Dupuis H, et al. Exposure to the RXR Agonist SR11237 in Early Life Causes Disturbed Skeletal Morphogenesis in a Rat Model. Int J Mol Sci. 2019;20(20):5198. Published 2019 Oct 20.

Related compound libraries

This product is contained In the following compound libraries:
Metabolism Compound Library Nuclear Receptor Compound Library Neuronal Differentiation Compound Library Transcription Factor-Targeted Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

SR11237 146670-40-8 Metabolism Others RAR/RXR  Retinoid X receptors bone BMS 649 transactivate BMS649 Retinoic acid receptors reporter ossification RAR/RXR inhibit Inhibitor RXR/RXR BMS-649 homodimers SR-11237 gene SR 11237 inhibitor

 

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