replication — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN2283	Tripterifordin		HIV Protease
	Tripterifordin shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.		HIV Protease
T38514	PMEDAP		Others , HIV Protease
	PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP also has anti-murine cytomega...		Others , HIV Protease
T38237	2′-O-Methylcytidine		Nucleoside Antimetabolite/Analog , HCV Protease
	2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 μM).1It inhibits HCV replication in a replicon assay (IC50= 21.2 μM). 1.Migliaccio, G....		Nucleoside Antimetabolite/Analog , HCV Protease
T11539	HCV-IN-29		HCV Protease
	HCV-IN-29 is a hepatitis C virus (HCV) inhibitor.		HCV Protease
T11541	HCV-IN-30		Others , HCV Protease
	HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons).		Others , HCV Protease
T1068	Dithranol	1,8,9-trihydroxyanthracene,cignoline,Anthralin	Others , DNA/RNA Synthesis
	Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.		Others , DNA/RNA Synthesis
T14495	Baloxavir	Baloxavir acid,S-033447	Influenza Virus
	Baloxavir (S-033447) is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.		Influenza Virus
T9212	IMB-301		Others , HIV Protease
	IMB-301 is a small molecular inhibitor via virtual screening according to the hA3G model.		Others , HIV Protease
T8354	Triazavirin		Nucleoside Antimetabolite/Analog , Influenza Virus , DNA/RNA Synthesis
	Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.
T11538	Hck-IN-1		HIV Protease , Src , Hck
	Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for w...		HIV Protease , Src , Hck
T11669	IR415		HBV
	IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 i...		HBV
T8371	ML188		Virus Protease , SARS-CoV
	ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.		Virus Protease , SARS-CoV
T6738	Z-FA-FMK		SARS-CoV , Cysteine Protease
	Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.		SARS-CoV , Cysteine Protease
T4527	Seclidemstat	SP-2577	Histone Demethylase
	Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.		Histone Demethylase
T9716	Ensitrelvir	S-217622	SARS-CoV
	Ensitrelvir (S-217622) is an orally active inhibitor of SARS-CoV-2 3CL protease with IC50 of 13 nM.		SARS-CoV
TWP2911	Thymidine	5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin	Others , DNA/RNA Synthesis , Endogenous Metabolite
	1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.		Others , DNA/RNA Synthesis , Endogenous Metabolite
T0220	Foscarnet sodium	Phosphonoformate	Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
	Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.		Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
T9350	IMP-1088		Others , DNA/RNA Synthesis
	IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.		Others , DNA/RNA Synthesis
T39477	Calcium trinatrium diethylenetriaminepentaacetic acid hydrate	Ca-DTPA trisodium salt hydrate	Others
	Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Ca-DTPA tris...		Others
T7318	Elimusertib	BAY-1895344	ATM/ATR
	Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target...		ATM/ATR