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Dithranol

Catalog No. T1068   CAS 1143-38-0
Synonyms: 1,8,9-trihydroxyanthracene, cignoline, Anthralin

Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.

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Dithranol Chemical Structure
Dithranol, CAS 1143-38-0
Pack Size Availability Price/USD Quantity
50 mg In stock $ 34.00
100 mg In stock $ 50.00
200 mg In stock $ 63.00
1 mL * 10 mM (in DMSO) In stock $ 37.00
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Purity: 93.49%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.
Kinase Assay THP-1 and HEK293 cells are transiently transfected using DEAE-dextran and Polyfect reagent, respectively. Plasmids transfected contain genes coding for the NF-κB-dependent pELAM-luc luciferase reporter, TLR2, TLR4, CD14, and MD2. Cells (5×105 THP-1 or 1×105 HEK293) are added to 12-well plates, washed after 18 h, and stimulated for 5 h. Cells are then lysed with reporter lysis buffer as directed, and lysates are analyzed for luminescence using Promega luciferase substrate and a Monolight 3010 luminometer.
Synonyms 1,8,9-trihydroxyanthracene, cignoline, Anthralin
Molecular Weight 226.23
Formula C14H10O3
CAS No. 1143-38-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform: 41 mg/mL

DMSO: 10 mM

TargetMolReferences and Literature

1. Durdu M, et al. J Am Acad Dermatol. 2015 Apr;72(4):640-50.

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Natural Product Library for HTS Cell Cycle Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Drug Repurposing Compound Library Polyphenolic Natural Product Library

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Keywords

Dithranol 1143-38-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Others DNA/RNA Synthesis plaques 1,8,9-trihydroxyanthracene repair cignoline replication psoriatic Anthralin DNA Inhibitor inhibit inhibitor

 

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