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IR415

Catalog No. T11669 CAS 452967-14-5

IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity.

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IR415, CAS 452967-14-5

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Purity: 98%

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Description	IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity.
Targets&IC50	Hepatitis B virus X protein (HBx):2 nM(Kd)
In vitro	IR415 (50-200 μM) has a dose-dependent inhibitory effect on HBx, with a minimal effective concentration of 50 μM in HepG2/GFP-shRNA line transfected with HBx.Hepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based silencing of viral genes.

Molecular Weight	296.34
Formula	C13H14F2N4S
CAS No.	452967-14-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (421.81 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ghosh S, et al. An RNAi-based high-throughput screening assay to identify small molecule inhibitors of hepatitis B virus replication.J Biol Chem. 2017 Jul 28;292(30):12577-12588.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IR415 452967-14-5 微生物学 HBV Inhibitor inhibit cell HepG2 HBX IR 415 IR-415 replication virus Hepatitis B virus VSR hepatitis B inhibitor

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