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Thymidine

Catalog No. TWP2911   CAS 50-89-5
Synonyms: 5-Methyldeoxyuridine, Deoxyribothymidine, DThyd, NSC 21548, Thymidin

1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.

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Thymidine Chemical Structure
Thymidine, CAS 50-89-5
Pack Size Availability Price/USD Quantity
500 mg In stock $ 45.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.85%
Purity: 99.32%
Purity: 99.27%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.
Synonyms 5-Methyldeoxyuridine, Deoxyribothymidine, DThyd, NSC 21548, Thymidin
Molecular Weight 242.23
Formula C10H14N2O5
CAS No. 50-89-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: Soluble

DMSO: 44 mg/mL(181.6 mM)

Pyridine, Methanol, etc.: Soluble

TargetMolReferences and Literature

1. Sun R , Wang L . Thymidine Kinase 2 Enzyme Kinetics Elucidate the Mechanism of Thymidine-Induced Mitochondrial DNA Depletion[J]. Biochemistry, 2014, 53(39):6142-6150.

TargetMolCitations

1. Zhao Y, Yang J, Lu D, et al.The Loss-Function of KNL1 Causes Oligospermia and Asthenospermia in Mice by Affecting the Assembly and Separation of the Spindle through Flow Cytometry and Immunofluorescence.Sensors.2023, 23(5): 2571. 2. Wang J, Chen Y, Li S, et al.PP2A inhibition causes synthetic lethality in BRCA2-mutated prostate cancer models via reactivating spindle assembly checkpoint.The Journal of Clinical Investigation.2023

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Tobacco Monomer Library Human Endogenous Metabolite Library Marine Natural Product Library RO5 Drug-like Natural Product Library Alkaloid Natural Product Library Human Metabolite Library Natural Product Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Traditional Chinese Medicine Monomer Library

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Thymidine 50-89-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Others DNA/RNA Synthesis Endogenous Metabolite 5-Methyldeoxyuridine Deoxyribothymidine DNA NSC21548 DThyd arrest synchronizing replication Inhibitor NSC-21548 NSC 21548 Thymidin precursor inhibit inhibitor

 

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