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Baloxavir

Catalog No. T14495   CAS 1985605-59-1
Synonyms: Baloxavir acid, S-033447

Baloxavir (S-033447) is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.

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Baloxavir Chemical Structure
Baloxavir, CAS 1985605-59-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 71.00
5 mg In stock $ 173.00
10 mg In stock $ 274.00
25 mg In stock $ 527.00
50 mg In stock $ 671.00
100 mg In stock $ 956.00
200 mg In stock $ 1,290.00
1 mL * 10 mM (in DMSO) In stock $ 184.00
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Purity: 99.89%
Purity: 99.46%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Baloxavir (S-033447) is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
In vitro Baloxavir (BXA) inhibits viral RNA transcription via selective inhibition of cap-dependent endonuclease (CEN) activity in enzymatic assays, and inhibits viral replication in infected cells without cytotoxicity in cytopathic effect assays, and it also inhibits cap-dependent endonuclease (CEN) and CEN/RdRp activities with IC50 values of 2.5 nM and 1.6 nM, respectively, while low potency (IC50 >40 nM) is observed against RdRp activity[2]. The median EC50 values at baseline for Baloxavir (BXA) are 17.96 nM for A/H1N1pdm, 4.48 nM for A/H3N2, and 18.67 nM for type B virus[1]. Baloxavir shows high potency against influenza A and B viruses with mean EC90 of 0.46 - 0.98 nM and 2.2-3.4 nM, respectively[2] and it also shows broad potency against various subtypes of influenza A viruses (H1N2, H5N1, H5N2, H5N6, H7N9 and H9N2). Additionally, serial passages of the viruses in the presence of Baloxavir result in isolation of PA/I38T variants with reduced BXA susceptibility[2]. Baloxavir (BXA) has a high inhibitory potency against CEN activity of the tested viral ribonucleoprotein complexes (vRNPs) from influenza A and B viruses with mean IC50 values of 1.4-3.1 nM and 4.5-8.9 nM, respectively, indicating that Baloxavir has broad spectrum activities.
Synonyms Baloxavir acid, S-033447
Molecular Weight 483.49
Formula C24H19F2N3O4S
CAS No. 1985605-59-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 47 mg/mL (97.21mM)

TargetMolReferences and Literature

1. Omoto S, et al. Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil. Sci Rep. 2018 Jun 25;8(1):9633. 2. Noshi T, et al. In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit. Antiviral Res. 2018 Dec;160:109-117.

Related compound libraries

This product is contained In the following compound libraries:
ReFRAME Related Library Bioactive Compound Library Human Metabolite Library Bioactive Compounds Library Max Inhibitor Library Anti-Infection Compound Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Approved Drug Library

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Keywords

Baloxavir 1985605-59-1 Microbiology/Virology Influenza Virus inhibit CEN BXA cap-dependent dolutegravir S033447 influenza Baloxavir acid RNA replication S 033447 endonuclease S-033447 Inhibitor transcription inhibitor

 

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