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Hck-IN-1

Catalog No. T11538   CAS 1473404-51-1

Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and <20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.

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Hck-IN-1 Chemical Structure
Hck-IN-1, CAS 1473404-51-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 133.00
2 mg In stock $ 189.00
5 mg In stock $ 289.00
10 mg In stock $ 453.00
25 mg In stock $ 747.00
50 mg In stock $ 1,050.00
100 mg In stock $ 1,420.00
1 mL * 10 mM (in DMSO) In stock $ 313.00
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Purity: 98.29%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.
Targets&IC50 HIV-1 Nef:100-300 nM
In vitro Hck-IN-1 inhibits the replication of all eleven HIV-1 Nef chimeras (IC50s: ~ 300 nM in CEM-T4 cells) demonstrating that the compound is broadly active against HIV replication supported by a wide range of HIV-1 Nef proteins.?Hck-IN-1 ?shows weak activity against other Src-family members in vitro, with IC50 values >20 μM for c-Src, Lck, and Lyn.??B9 (1 μM;?8 days) completely inhibits Nef-dependent SFK activation at a concentration of 1.0 μM.??Hck-IN-1 (0.1, 0.3, 1, 3 μM) also inhibits Nef-mediated enhancement of HIV-1 infectivity in a concentration-dependent manner in the reporter cell line, TZM-bl.
Molecular Weight 402.81
Formula C16H11ClN6O3S
CAS No. 1473404-51-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12.5 mg/mL (31.03 mM), sonification is recommended.

TargetMolReferences and Literature

1. Emert-Sedlak LA, et al. Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. Chem Biol. 2013 Jan 24;20(1):82-91.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Viral Compound Library Anti-Cancer Compound Library Angiogenesis related Compound Library Bioactive Compound Library Anti-Pancreatic Cancer Compound Library Reprogramming Compound Library Bioactive Compounds Library Max Anti-Infection Compound Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library

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Absinthin Schisantherin D AMD 3465 (S)-BI-1001 NNRTIs-IN-3 HIV-1 protease-IN-8 HIV-1 protease-IN-9 HIV-1 protease-IN-11

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Keywords

Hck-IN-1 1473404-51-1 Angiogenesis Microbiology/Virology Proteases/Proteasome Tyrosine Kinase/Adaptors HIV Protease Src Hck anti-retroviral Nef diphenylpyrazolo Hck IN 1 Nef:Hck Nef-dependent replication Inhibitor HIV inhibit HckIN1 Human immunodeficiency virus Asn126 inhibitor

 

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