Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and <20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 133.00 | |
2 mg | In stock | $ 189.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 453.00 | |
25 mg | In stock | $ 747.00 | |
50 mg | In stock | $ 1,050.00 | |
100 mg | In stock | $ 1,420.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 313.00 |
Description | Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication. |
Targets&IC50 | HIV-1 (Nef):100-300 nM |
In vitro | Hck-IN-1 inhibits the replication of all eleven HIV-1 Nef chimeras (IC50s: ~ 300 nM in CEM-T4 cells) demonstrating that the compound is broadly active against HIV replication supported by a wide range of HIV-1 Nef proteins. Hck-IN-1 shows weak activity against other Src-family members in vitro, with IC50 values >20 μM for c-Src, Lck, and Lyn. B9 (1 μM; 8 days) completely inhibits Nef-dependent SFK activation at a concentration of 1.0 μM. Hck-IN-1 (0.1, 0.3, 1, 3 μM) also inhibits Nef-mediated enhancement of HIV-1 infectivity in a concentration-dependent manner in the reporter cell line, TZM-bl. |
Molecular Weight | 402.81 |
Formula | C16H11ClN6O3S |
CAS No. | 1473404-51-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.5 mg/mL (31.03 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Hck-IN-1 1473404-51-1 Angiogenesis Microbiology/Virology Proteases/Proteasome Tyrosine Kinase/Adaptors HIV Protease Hck Src anti-retroviral Nef diphenylpyrazolo Hck IN 1 Nef:Hck Nef-dependent replication Inhibitor HIV inhibit HckIN1 Human immunodeficiency virus Asn126 inhibitor