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Hck-IN-1

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Purity:98.29%

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COA LCMS HNMR

Hck-IN-1

Catalog No. T11538Cas No. 1473404-51-1

Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.

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Pack Size	Price	Availability
1 mg	$133	In Stock
2 mg	$189	In Stock
5 mg	$289	In Stock
10 mg	$453	In Stock
25 mg	$747	In Stock
50 mg	$1,050	In Stock
100 mg	$1,420	In Stock
1 mL x 10 mM (in DMSO)	$313	In Stock

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Product Introduction

Bioactivity

Description

In vitro

Hck-IN-1 inhibits the replication of all eleven HIV-1 Nef chimeras (IC50s: ~ 300 nM in CEM-T4 cells) demonstrating that the compound is broadly active against HIV replication supported by a wide range of HIV-1 Nef proteins. Hck-IN-1 shows weak activity against other Src-family members in vitro, with IC50 values >20 μM for c-Src, Lck, and Lyn. B9 (1 μM; 8 days) completely inhibits Nef-dependent SFK activation at a concentration of 1.0 μM. Hck-IN-1 (0.1, 0.3, 1, 3 μM) also inhibits Nef-mediated enhancement of HIV-1 infectivity in a concentration-dependent manner in the reporter cell line, TZM-bl.

Chemical Properties

Molecular Weight	402.81
Formula	C16H11ClN6O3S
Cas No.	1473404-51-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12.5 mg/mL (31.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4826 mL	12.4128 mL	24.8256 mL	124.1280 mL
5 mM	0.4965 mL	2.4826 mL	4.9651 mL	24.8256 mL
10 mM	0.2483 mL	1.2413 mL	2.4826 mL	12.4128 mL
20 mM	0.1241 mL	0.6206 mL	1.2413 mL	6.2064 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc