pathway — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13345	Wnt pathway activator 2		Others , Wnt/beta-catenin
	Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.		Others , Wnt/beta-catenin
T17256	Wnt pathway activator 1		Wnt/beta-catenin
	Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM. Wnt pathway activator 1 is a potent Wnt activator for the treatment of androgenetic alopecia (AGA).		Wnt/beta-catenin
T77502	Wnt pathway inhibitor 3		Wnt/beta-catenin , Adenylyl cyclase
	Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies to ameliorate osteoarthritis in a mouse model of experimenta...		Wnt/beta-catenin , Adenylyl cyclase
T77716	Wnt pathway inhibitor 4		Antibacterial
	Wnt pathway inhibitor 4 is a small molecule antimicrobial agent with antibacterial and antiproliferative activity against cancer cells.		Antibacterial
T3156	Ciliobrevin A	Hedgehog Pathway Inhibitor 4,HPI-4	Hedgehog/Smoothened
	Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.		Hedgehog/Smoothened
T38519	YB-0158	Wnt pathway inhibitor 2,YB-0158
	YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a r...
T25502	HIF-IN-33	HIF IN 33,HIF Pathway Inhibitor 33
	HIF-IN-33 is an inhibitor of HIF pathway.
T12246	CB-103		Gamma-secretase
	CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.		Gamma-secretase
T9810	TNIK-IN-5		Wnt/beta-catenin
	TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.		Wnt/beta-catenin
T12885	SGC-AAK1-1		AAK1 (AP2 associated kinase 1)
	SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe.		AAK1 (AP2 associated kinase 1)
T9165	AZD5305		PARP
	AZD5305 is a potent, selective and oral active PARP inhibitor.		PARP
T4766	3-Methylglutaric acid		Endogenous Metabolite
	Methylglutaric acid is a leucine metabolite. A large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme A hydratase (PMID 6181239 ). Methylglutaric acid is als...		Endogenous Metabolite
T5210	BAI1		Apoptosis , BCL
	BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).		Apoptosis , BCL
T19857	Glyphosate	Atila,Lancer,Folusen	Apoptosis , Autophagy
	Glyphosate (Atila) is an herbicide. It also is a possible carcinogen to humans.		Apoptosis , Autophagy
T41286	N6-Isopentenyladenosine		Endogenous Metabolite , Autophagy
	N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity. N6-Isopentenyladenosine, an RNA modification found in cytokinins, regulates plant growth/different...		Endogenous Metabolite , Autophagy
T5486	RU.521	RU320521	DNA , cGAS
	RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.		DNA , cGAS
T5465	PF-5274857	PF-5274857 freebase	Smo
	PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t...		Smo
T14327	AS1949490		Phosphatase
	AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2]. AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2) inhibitor, with an IC50 of 620 nM.		Phosphatase
T3912	Saikosaponin B1		Others
	Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.		Others
T20723	LGE-899	Sonidegib metabolite M48,LGE 899	Drug Metabolite
	LGE-899 (Sonidegib metabolite M48) is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than Sonidegib.		Drug Metabolite