Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
50 mg | In stock | $ 45.00 | |
100 mg | In stock | $ 55.00 | |
200 mg | In stock | $ 80.00 | |
500 mg | In stock | $ 133.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity. |
In vitro | CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines, and?exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines[2]. |
In vivo | CB-103?inhibits growth of GSI/Mab resistant triple negative breast cancer, and?exhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors[3]. |
Molecular Weight | 242.32 |
Formula | C15H18N2O |
CAS No. | 218457-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 230 mg/mL (949.16 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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CB-103 218457-67-1 Neuroscience Proteases/Proteasome Stem Cells Gamma-secretase CB 103 pathway CB103 inhibit Inhibitor Notch signaling leukemia inhibitor