melanoma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T62291	Anti-melanoma agent 1
	Anti-melanoma agent 1 (Compound 5m) is an anti-melanoma agent that induces apoptosis.
T9521	CHR-6494 TFA		Others
	CHR-6494 TFA is a potent haspin inhibitor, with an IC50 of 2 nM. It inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be use...		Others
T9135	Epirosmanol		Others
	Epirosmanol is a diterpenoid containing a lactone moiety. Epirosmanol is a very weakly basic (essentially neutral) compound (based on its pKa).		Others
T8566	AA92593		Others
	AA92593 has been used as a selective inhibitor of melanopsin.		Others
T9148	KA2507		HDAC
	KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.		HDAC
T9693	TBAP-001		Raf
	TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.		Raf
TN2069	Picrocrocin		Apoptosis
	Picrocrocin is a natural product		Apoptosis
T10477	BAY-985		IκB/IKK
	BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with antitumor efficacy.		IκB/IKK
T3560	Desmethylanethol trithione	ADT-OH	VEGFR , Akt
	Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly...		VEGFR , Akt
T1867	Otenaproxesul	ATB 346	Apoptosis , COX
	Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.		Apoptosis , COX
T35407	Ζ-Stat		PKC
	ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in melanoma cell lines, exhibiting antitumor activity in vitro[1]...		PKC
T21679	4'-bromo-Resveratrol		Sirtuin
	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)		Sirtuin
T41286	N6-Isopentenyladenosine		Endogenous Metabolite , Autophagy
	N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity. N6-Isopentenyladenosine, an RNA modification found in cytokinins, regulates plant growth/different...		Endogenous Metabolite , Autophagy
T11553	Heptamidine dimethanesulfonate	SBi4211 dimethanesulfonate	Others
	Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) serves as a potent inhibitor related to Pentamidine, targeting the calcium-binding protein S100B with a dissociation constant (Kd) of 6.9 µM. It demonstrates sp...		Others
T24269	KPT-251	KPT251	Others
	KPT-251 is a selective nuclear export inhibitor.		Others
T8745	PROTAC BRAF-V600E degrader-1	Compound 23	Raf
	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.		Raf
T1120	Dacarbazine	Imidazole Carboxamide,DTIC-Dome	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.
T5S0055	Chelidonine	Helidonine,Khelidonin,Stylophorin	Apoptosis , Others , Influenza Virus
	1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model ...		Apoptosis , Others , Influenza Virus
T6609	NMS-E973		HSP
	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.		HSP
T1310	2-Thiouracil	Thiouracil,Deracil	Thyroid hormone receptor(THR) , NO Synthase
	2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.		Thyroid hormone receptor(THR) , NO Synthase