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Dacarbazine

Catalog No. T1120   CAS 4342-03-4
Synonyms: Imidazole Carboxamide, DTIC-Dome

Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.

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Dacarbazine Chemical Structure
Dacarbazine, CAS 4342-03-4
Pack Size Availability Price/USD Quantity
50 mg In stock $ 32.00
100 mg In stock $ 50.00
200 mg In stock $ 58.00
1 g In stock $ 97.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.
In vitro Treatment of Dacarbazine sensitizes melanomas to lysis of peptide-specific CTL and it is is mediated through Fas-independent pathway[2].
In vivo Treatment of combination of Axitinib and DTIC demonstrates significant antitumor activity against melanoma flank xenografts, reduces tumor cell proliferation and decreases the area of tumor necrosis and increases apoptosis. It also reduces meta-tasis-related factors and prolongs lifespan in mice[3].
Cell Research Apotosis assay: UACC903 (UACC) cells treated with or without DTIC (20 μM) for 48 h are incubated with agonist anti-Fas Ab, CH-11 (500 ng/ml), for 5 and 16 h, respectively. To distinguish whether death/apoptosis is mediated by FasR, blocking anti-Fas Ab ZB4 (2 mg/ml) is added in the corresponding groups. At the end of incubation, cells are harvested and stained with propidium iodide and FITC-annexin V (BD PharMingen) for detecting apoptosis according to the instruction provided by the company. Ten thousand cells from each group are collected, and dead and apoptotic cells are analyzed without gating using CellQuest software. (Only for Reference)
Synonyms Imidazole Carboxamide, DTIC-Dome
Molecular Weight 182.18
Formula C6H10N6O
CAS No. 4342-03-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 3 mg/mL (16.46 mM)

TargetMolReferences and Literature

1. Serrone L, et al. J Exp Clin Cancer Res. 2000, 19(1):21-34. 2. Yang S, et al. J Immunol. 2004, 172(7):4599-608. 3. Zhang XH, et al. Oncol Lett. 2013, 6(1):69-74.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Traditional Chinese Medicine Monomer Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Reprogramming Compound Library Approved Drug Library Apoptosis Compound Library Chemotherapy Drug Library

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Keywords

Dacarbazine 4342-03-4 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis Nucleoside Antimetabolite/Analog B cell inhibit antineoplastic Inhibitor Imidazole Carboxamide T cell DTIC-Dome metastatic malignant melanoma inhibitor

 

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