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Ζ-Stat

Catalog No. T35407 CAS 3316-02-7

ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in melanoma cell lines, exhibiting antitumor activity in vitro[1][2].

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Ζ-Stat, CAS 3316-02-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 119.00
5 mg	In stock	$ 297.00
10 mg	In stock	$ 472.00
25 mg	In stock	$ 777.00
50 mg	In stock	$ 1,090.00
100 mg	In stock	$ 1,460.00
500 mg	In stock	$ 2,930.00

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Description	ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in melanoma cell lines, exhibiting antitumor activity in vitro[1][2].
Targets&IC50	PKCζ:5 μM
In vitro	ζ-Stat (0.1-20 μM) shows only 13% inhibition on PKC-Ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1].ζ-Stat (0.1-10 μM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1].ζ-Stat (7 or 10 μM; 24-72?h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2].ζ-Stat (5 μM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1].ζ-Stat (5 μM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1].

Molecular Weight	384.36
Formula	C10H8O10S3
CAS No.	3316-02-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 62.5 mg/mL (162.61 mM), Sonication is recommended.

References and Literature

1. Ratnayake WS, et, al. Oncogenic PKC-Ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-Ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463. 2. Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library TGF-beta/Smad Compound Library Anti-Cancer Active Compound Library Bioactive Compound Library Anti-Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Epigenetics Compound Library

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Keywords

Ζ-Stat 3316-02-7 Chromatin/Epigenetic Cytoskeletal Signaling PKC antitumor NSC 37044 melanoma ζ-Stat NSC-37044 kinase NSC37044 Protein kinase C ΖStat atypical Inhibitor Apoptosis protein Ζ Stat inhibit PKC-ζ inhibitor

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