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Desmethylanethol trithione

Catalog No. T3560 CAS 18274-81-2

Synonyms: ADT-OH

Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, Desmethylanethol trithione improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.

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Desmethylanethol trithione Chemical Structure

Desmethylanethol trithione, CAS 18274-81-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 57.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 166.00
100 mg	In stock	$ 265.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 98.19%

Purity: 98.05%

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Description

In vitro

In glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion.

Synonyms	ADT-OH
Molecular Weight	226.34
Formula	C9H6OS3
CAS No.	18274-81-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (198.82 mM)

References and Literature

1. Hasegawa U,et al. Hydrolysis-Sensitive Dithiolethione Prodrug Micelles. Macromol Biosci. 2015 Nov;15(11):1512-22.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Tyrosine Kinase Inhibitor Library Bioactive Compound Library Glycolysis Compound Library Anti-Breast Cancer Compound Library Stem Cell Differentiation Compound Library Glutamine Metabolism Compound Library Neuronal Differentiation Compound Library Anti-Cardiovascular Disease Compound Library

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Keywords

Desmethylanethol trithione 18274-81-2 Angiogenesis Cytoskeletal Signaling PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors Akt VEGFR ADT-OH Inhibitor hydrogen sulfide-releasing ACS-1 ACS 1 cancer Apoptosis melanoma inhibit FADD ACS1 inhibitor

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