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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8564 | BC-1382 | Others , E1/E2/E3 Enzyme | |
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM). | |||
T14676 | BMS-688521 | Integrin | |
BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity. | |||
T8189 | Dihydroberberine | Potassium Channel , HSP , HER | |
Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interacti... | |||
T77666 | MoTPS1-IN-1 | Antifungal | |
MoTPS1-IN-1 is a potent MoTPS1 inhibitor with antifungal and potentially anti-inflammatory activity that acts through interaction with Glu396 and can be used to study ulcerative colitis. | |||
T76704 | Tralokinumab | CAT-354,LP 0162 | IL Receptor |
Tralokinumab is a fully human IgG4 monoclonal antibody with a high affinity for IL-13 alone. Tralokinumab's potential anti-inflammatory activity prevents IL-13 receptor interaction and subsequent downstream signaling and... | |||
T2S2173 | (E)-Naringenin chalcone | Isosalipurpol,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone | Others |
Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid tha... | |||
T77125 | Otilimab | GSK 3196165,MOR103 | CSF-1R |
Otilimab (GSK 3196165) is a humanized monoclonal antibody against granulocyt-macrophage colony-stimulating factor (GM-CSF). Otilimab has anti-inflammatory activity, regulates the biological function of GM-CSF by blocking... | |||
T36953 | Naphthofluorescein | Naphthafluorescein | HIF |
Naphthofluorescein (Naphthafluorescein) is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhib... | |||
TN6872 | Trypsin | Protease-activated Receptor | |
Trypsin is a serine protease that can be isolated from fish to hydrolyze lysine or arginine carboxy-side proteins. With the anti-inflammatory activity, Trypsin could induce the cell membrane fusion of PDCoV-infected cell... | |||
TMA0291 | Dehydroglyasperin D | GSK-3 , p38 MAPK , ROS , Akt , COX , PI3K , DNA/RNA Synthesis , Prostaglandin Receptor , JNK | |
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction wit... | |||
TN6570 | Daturaolone | ||
Daturaolone has potency in reducing the harmful effects or in maintaining the normal hepatic physiological mechanisms in both acute and chronic hepato-toxic induced liver damage in rats. Daturaolone also possesses in viv... | |||
T83057 | Anti-inflammatory agent 49 | ||
Compound SC9, an anti-inflammatory agent, serves as a potent and selective inhibitor of the Drp1-Fis1 interaction, mitigating FIS1-mediated mitochondrial dysfunction. It exhibits an in vitro IC50 value of 270 nM for inhi... | |||
T76034 | Cortistatin-14 TFA | ||
Cortistatin-14 (TFA), a neuropeptide resembling somatostatin-14 in structure, operates through interaction with somatostatin receptors (sst1-sst5). This compound exhibits anticonvulsive and neuroprotective effects alongs... | |||
T73665 | Bufrolin | ||
Bufrolin, an analog of Cromoglycate (histamine release inhibitor) and a potent agonist of GPR35, enhances the interaction between β-arrestin-2 and both human GPR35a and rat GPR35. It stabilizes mast cells, exhibiting ant... | |||
T76840 | Vunakizumab | ||
Vunakizumab (Anti-Human IL17A Recombinant Antibody), a recombinant human IgGκ monoclonal antibody, specifically targets and inhibits IL-17A's interaction with its receptor, making it useful for researching autoimmune con... | |||
T72412 | Antimicrobial agent-5 | ||
Antimicrobial Agent-5 is a potent antimicrobial agent that exhibits exceptional cell selectivity against both Gram-negative and Gram-positive bacteria. It inhibits the interaction between LPS (lipopolysaccharide) and the... | |||
T63987 | Keap1-Nrf2-IN-14 | ||
Keap1-Nrf2-IN-14 is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50: 75 nM) with a Kd=24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and is able to enhance... | |||
T60447 | α-Amylase-IN-3 | ||
α-Amylase-IN-3 (Compound 4) is a non-competitive inhibitor of α-Amylase with an IC50 value of 18.04 μM. α-Amylase-IN-3 has radical scavenging activities with IC50 values of 16.04 μM for DPPH and 16.99 μM for ABTS, respec... | |||
T36486 | Benpyrine | ||
Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten... | |||
TP2109 | TAT 14 | Nrf2 | |
Nrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells. |