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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5399 | GeA-69 | PARP | |
GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays). | |||
T0373 | Erlotinib | OSI-744,NSC 718781,CP358774,R1415 | EGFR , Autophagy |
Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer. | |||
T7724 | Tepoxalin | RWJ-20485,RWJ20485,ORF20485,ORF-20485,RWJ 20485,ORF 20485 | Lipoxygenase , COX |
Tepoxalin (RWJ 20485) is a 5-lipoxygenase inhibitor potentially for the treatment of asthma, osteoarthritis. Tepoxalin inhibits COX-1, COX-2, and 5-LOX. Tepoxalin is a potent inhibitor of sheep seminal vesicle cyclooxyge... | |||
T9810 | TNIK-IN-5 | Wnt/beta-catenin | |
TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity. | |||
T6040 | Aloxistatin | E64d,Loxistatin,E64c ethyl ester | SARS-CoV , Cysteine Protease |
Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with... | |||
T12913 | Siguazodan | SKF 94836 | PDE |
Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM. Siguazodan inhibited phenylephrine induced 5-HT release with an IC50 value of 4.2 μM。 S... | |||
T38651 | Lauryl maltose neopentyl glycol | LMNG | |
Lauryl maltose neopentyl glycol (LMNG) is a detergent that solubilizes and stabilizes membrane proteins. lauryl maltose neopentyl glycol extracts intact membrane proteins from membranes, thereby improving the stability o... | |||
T3889 | Platycodin D | Prostaglandin Receptor , AMPK | |
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1... | |||
T16087 | Quiflapon | MK-591 | Apoptosis , FLAP |
Quiflapon (MK-591) causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) and is also an effective and orally active Leukotr... | |||
TP2008L | Lyn peptide inhibitor acetate | Lyn peptide inhibitor acetate(222018-18-0 free base) | IL Receptor |
Lyn peptide inhibitor acetate is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the bind... | |||
TP1956L | PKC ζ pseudosubstrate acetate | PKC ζ pseudosubstrate acetate (799764-07-1 free base) | PKC |
PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by... | |||
T1467 | Acemetacin | K-708,TVX 1322 | COX |
Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metaboli... | |||
T68095 | Losulazine | Dopamine Receptor , Norepinephrine | |
Losulazine is a peripheral sympathetic antihypertensive compound that can be taken orally. Losulazine causes relatively modest, transient depletion of dopamine and norepinephrine in brain regions protected by the blood-b... | |||
T29600 | Acetylethylcholine mustard | Aech-M | |
Acetylethylcholine mustard can effect muscarinic receptor-coupled attenuation of cAMP formation for intact GH3 cells. | |||
T26172 | S3QEL-2 | S3QEL2,S3QEL 2 | |
S3QEL-2 is a retrograde signaling modulator. It acts by strongly mitigating the oxidative stress-induced apoptosis that limits the yield of functional ß-cells from intact islets. | |||
T68859 | Rudolfomycin | ||
Rudolfomycin is a class II anthracycline antitumor antibiotic that inhibit the synthesis of nucleolar RNA in intact tumor cells. | |||
T24527 | Netzahualcoyone | ||
Netzahualcoyone inhibited the respiration of intact cells of B. subtilis but had no effect on the respiration of E. coli. | |||
TP2395 | Nph-peptide | ||
Nph-peptide can be used for photoaffinity labeling of the N-formyl peptide receptor site of intact human polymorphonuclear leukocytes. | |||
T29465 | 5-Oxodecanoic acid | 5-Ketocapric acid,5-Oxocapric acid | |
5-Oxodecanoic acid is a biochemical. 5-Oxodecanoic acid can be reducced to 5-hydroxydecanoic acid by intact cells of baker's yeast. | |||
TP1903 | PKG inhibitor peptide | cGMP Dependent Kinase Inhibitor Peptide | |
Competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit pho... |