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Acemetacin

Catalog No. T1467 CAS 53164-05-9

Synonyms: TVX 1322, K-708

Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin.

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Acemetacin, CAS 53164-05-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin.
Targets&IC50	COX-1:85 μM (IC50, in human intact cell)

Synonyms	TVX 1322, K-708
Molecular Weight	415.82
Formula	C21H18ClNO6
CAS No.	53164-05-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

DMSO: 77 mg/mL (185.2 mM)

Ethanol: 54 mg/mL (129.9 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Tavares IA, et al. Int J Tissue React, 1993, 15(2), 49-53. 2. Chávez-Piña AE, et al. Br J Pharmacol. 2007 Nov;152(6):930-8. 3. Gil-Flores M, et al. Methods Find Exp Clin Pharmacol. 2010 Mar;32(2):101-5. 4. Wada Y, et al. Jpn J Pharmacol, 1984 , 34(4), 468-470. 5. Gil-Flores M, et al. Methods Find Exp Clin Pharmacol, 2010, 32(2), 101-105.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Acemetacin 53164-05-9 Immunology/Inflammation Neuroscience COX TVX1322 TVX-1322 inhibit TVX 1322 Cyclooxygenase K-708 Inhibitor inhibitor

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