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Acemetacin

Acemetacin
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Purity:99.26%
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Acemetacin

Catalog No. T1467Cas No. 53164-05-9
Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin.
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Pack SizePrice/USDAvailabilityQuantity
200 mg$29In Stock
1 mL x 10 mM (in DMSO)$46In Stock
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Product Introduction

Bioactivity
Description
Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin.
In vitro
In rats pre-treated with COX-2 and NOS inhibitors, despite significant inhibition of COX activity, Acemetacin significantly reduces gastrointestinal damage compared to Indomethacin.
In vivo
Acemetacin exerts its anti-inflammatory effect by inhibiting the synthesis of prostaglandins (PG). In inflamed synovial tissue, Acemetacin (10 μM) prevents the release of Prostaglandin E2 (PGE2). It inhibits the release of prostaglandin E2 in joint synovial tissues in vitro. During the incubation of gastric mucosa, the concentration-dependent inhibition of PGE accumulation by Acemetacin is not as effective as Indomethacin, and its reduction effect on gastric 6-keto-PGF1α and thromboxane B2 is also lower than that of Indomethacin.
AliasK-708, TVX 1322
Chemical Properties
Molecular Weight415.82
FormulaC21H18ClNO6
Cas No.53164-05-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 54 mg/mL (129.9 mM)
DMSO: 77 mg/mL (185.2 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.4049 mL12.0244 mL24.0489 mL120.2443 mL
5 mM0.4810 mL2.4049 mL4.8098 mL24.0489 mL
10 mM0.2405 mL1.2024 mL2.4049 mL12.0244 mL
20 mM0.1202 mL0.6012 mL1.2024 mL6.0122 mL
50 mM0.0481 mL0.2405 mL0.4810 mL2.4049 mL
100 mM0.0240 mL0.1202 mL0.2405 mL1.2024 mL

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