hypotensive — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13482	2'-O-Methyladenosine		Endogenous Metabolite
	2'-O-Methyladenosine, a methylated adenine residue is found in the urine of normals and adenosine deaminase deficient patients. It shows unique hypotensive activities.		Endogenous Metabolite
T10900	CUDA		PPAR , Epoxide Hydrolase
	CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR...		PPAR , Epoxide Hydrolase
T4036	Solasodine	Solancarpidine,Purapuridine,Solasodin	Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
	Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma...		Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
T28360	PF-00489791	PF-4634817,PF 4634817,PF00489791,PF 00489791,PF4634817	PDE
	PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.		PDE
T21957	Guanabenz hydrochloride	NE56490	Adrenergic Receptor
	Guanabenz hydrochloride (NE56490) is an orally active α2-adrenoceptor agonist with hypotensive effects.		Adrenergic Receptor
TQ0185	14-Deoxy-11,12-didehydroandrographolide	AP10,14-dehydro Andrographolide	NF-κB
	14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.		NF-κB
T26923	Bunazosin Hydrochloride	E 1015,E643,E-1015,E-643,E 643	Adrenergic Receptor
	Bunazosin Hydrochloride (E 1015) is an alpha(1)-adrenoceptor antagonist used as a systemic antihypertensive and an ocular hypotensive drug.		Adrenergic Receptor
T5721	Dehydroevodiamine hydrochloride		AChE
	Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.		AChE
T24932	Vatanidipine	AE-0047,AE 0047,AE0047	Calcium Channel
	Vatanidipine (AE0047) is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.A slow-onset and long-lasting hypotensive action was observed in various experimental hypertensi...		Calcium Channel
T2S2335	Dehydroevodiamine	DHED	Others , NF-κB , COX , PGE Synthase , NO Synthase
	Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood fl...		Others , NF-κB , COX , PGE Synthase , NO Synthase
T3S1729	Dihydrolycorine		Others
	1. Dihydrolycorine-HCL(DL) shows hypotensive effects, it can block alpha 1-adrenoceptors. 2. Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inh...		Others
T8198	Visnagin		Others
	Visnagin has acute hypotensive, anti-inflammatory, and neuroprotective effects, it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.		Others
T3013	Catharanthine tartrate	Catharanthine hemitartrate	Others , Calcium Channel
	Catharanthine tartrate (Catharanthine hemitartrate) is an alkaloid from periwinkle that inhibits voltage-gated L-type calcium channels and has antitumor and hypotensive activities.		Others , Calcium Channel
TN2322	Yangambin		Calcium Channel , PAFR
	Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti...		Calcium Channel , PAFR
T0028	Gamibetal	3-Hydroxy-GABA,4-Amino-3-hydroxybutyric Acid	HIV Protease
	Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in the preparation of HIV-1 inhibitors derived from Betulinic Ac...		HIV Protease
T3S0629	Delsoline	Belsoline	Others
	1. Delsoline (Belsoline) has hypotensive effects.2. Delsoline is not only effective in preventing ventricular fibrillation and arrythmia, but can raise the intebsity of the threthold of electrical shocks to cause ventric...		Others
TP1917L1	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)	Bradykinin Receptor
	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cl...		Bradykinin Receptor
TP1918L	Lys-[Des-Arg9]Bradykinin,TFA	Lys-[Des-Arg9]Bradykinin,TFA 71800-36-7(fb-tfa)	Bradykinin Receptor
	Lys-[Des-Arg9]Bradykinin,TFA is Endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripher...		Bradykinin Receptor
T15824	Lysergol		Antibacterial
	Lysergol has been used as a hypotensive, psychotropic analgesic, and uterus- and intestine-stimulating drug. Lysergol is a clavinet alkaloid isolated from seeds of Ipomoea muricata and is a bioenhancer for the drugs and ...		Antibacterial
T22398	Phenidone	1-phenyl-3-pyrazolidinone	Lipoxygenase , COX
	Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxyg...		Lipoxygenase , COX