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Vatanidipine

Catalog No. T24932 CAS 116308-55-5

Synonyms: AE-0047, AE 0047, AE0047

Vatanidipine (AE0047) is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.A slow-onset and long-lasting hypotensive action was observed in various experimental hypertensive models.

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Vatanidipine, CAS 116308-55-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 329.00
5 mg	In stock	$ 798.00
10 mg	In stock	$ 1,090.00
25 mg	In stock	$ 1,650.00
50 mg	In stock	$ 2,230.00
100 mg	In stock	$ 2,930.00
1 mL * 10 mM (in DMSO)	In stock	$ 1,280.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Vatanidipine (AE0047 ) (10 and 50 ng/kg/min) was administered intrarenally, increases in the basal renal blood flow and urine formation were observed. During Vatanidipine (50 ng/kg/min) infusion, low-frequency RNS-induced antidiuretic action and increase in NESR were markedly attenuated. In addition, high-frequency RNS-induced renal vasoconstriction was significantly suppressed by Vatanidipineinfusion at higher doses. Lower doses of Vatanidipine (10 ng/kg/min) tended to attenuate the low- and high-frequency RNS-induced antidiuretic actions, although neither of the RNS-induced increases in NESR were suppressed by lower doses of Vatanidipine[2].

Synonyms	AE-0047, AE 0047, AE0047
Molecular Weight	686.8
Formula	C41H42N4O6
CAS No.	116308-55-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (40.04 mM)

References and Literature

1. Matsumura Y, Hayashi K. Vatanidipine hydrochloride: a new long-lasting antihypertensive agent. Expert Opin Investig Drugs. 2001 Jan;10(1):139-55. 2. Yamasaki T, et al. Inhibitory effects of AE0047, a new dihydropyridine Ca(2+) channel blocker, on renal nerve stimulation-induced renal actions in anesthetized dogs. J Pharmacol Exp Ther. 2000 Jun;293(3):1040-7.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

Azelnidipine Manidipine N6-(2-Hydroxyethyl)adenosine Procyanidin A1 Pranidipine Turkesterone Fluspirilene Ziconotide Acetate (107452-89-1 free base)

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Vatanidipine 116308-55-5 Membrane transporter/Ion channel Metabolism Calcium Channel AE-0047 AE 0047 AE0047 inhibitor inhibit

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