homologous — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11014	DFP00173		Aquaporin
	DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous AQP subtypes AQP7 and AQP9, DFP00173 is selective for AQP3.		Aquaporin
T9756	AZD-9574		PARP
	AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.		PARP
T2276	RI-1	RI1,RAD51 inhibitor 1	DNA/RNA Synthesis
	RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).		DNA/RNA Synthesis
T8806	Fluzoparib	HS10160,SHR3162	PARP
	Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours.		PARP
TN2444	Batatasin IV		Others
	Batatasin IV is identified from Dioscorea opposita which is a a type of homologous medicinal plant and is commonly used as food in daily life.		Others
T2628	RI-2		DNA/RNA Synthesis
	RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.		DNA/RNA Synthesis
T8880	PFM01		Others
	PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).		Others
T23974	DDRI-18	DDRI18,DDRI 18	DNA/RNA Synthesis
	DDRI-18 is a novel small molecule inhibitor that regulates the DNA damage response with sensitizing and anticancer activities, inhibits non-homologous end-joining (NHEJ) DNA repair and enhances the cytotoxicity of antica...		DNA/RNA Synthesis
T8637	DMNB	6-Nitroveratraldehyde	DNA-PK
	DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c...		DNA-PK
T4339	YU238259		DNA-PK , Others
	YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.		DNA-PK , Others
T6960L	PU-H71 HCl	PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl	HSP , DNA/RNA Synthesis
	PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of maligna...		HSP , DNA/RNA Synthesis
T23840	BUR1	BMP upregulator-1,BMP upregulator 1,BUR 1,BUR-1	CDK
	BUR1 is a selective BMP upregulator that acts by increasing the expression of Inhibitor of DNA binding 1 and inducing BMP2 and PTGS2 expression.		CDK
T63730	NRX-103095		Wnt/beta-catenin
	NRX-103095 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP and enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 163 nM.		Wnt/beta-catenin
T83976	ARB-272572 hydrochloride	ARB-272572 hydrochloride（2368182-63-0 Free base）	PD-1/PD-L1
	ARB-272572 hydrochloride is a small molecule PD-L1 inhibitor with an IC50 value of 400 pM for PD-1/PD-L1 HTRF.ARB-272572 hydrochloride inhibits PD-1/PD-L1 cell signaling by inducing homologous interactions with PD-L1 pro...		PD-1/PD-L1
T63427	NRX-103094	NRX103094,NRX 103094	Wnt/beta-catenin
	NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.		Wnt/beta-catenin
T10981	DCZ0415		Apoptosis , Others , NF-κB
	DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can impair the repair of non-homologous end junctions and inhibit ...		Apoptosis , Others , NF-κB
TP1120L	IRBP acetate(211426-18-5 free base)	Interphotoreceptor Retinoid Binding Protein Fragment IRBP	Others
	IRBP acetate(211426-18-5 free base) (Interphotoreceptor Retinoid Binding Protein Fragment IRBP) is a 20-residue peptide, which is a major pathogenic epitope. It exists in the first homologous repeat of interstitial visua...		Others
TQ0232	UNC0646	UNC 0646	Histone Methyltransferase
	UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells ...		Histone Methyltransferase
T14565	BI-671800	AP-761,Cmpd A	GPR , Prostaglandin Receptor
	BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2...		GPR , Prostaglandin Receptor
T63228	Simmiparib	SMOCL-9112	Apoptosis , PARP
	Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient...		Apoptosis , PARP