Powder: -20°C for 3 years | In solvent: -80°C for 2 years
PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 123.00 | |
50 mg | In stock | $ 228.00 | |
100 mg | In stock | $ 372.00 | |
200 mg | In stock | $ 517.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR). |
In vitro | PFM01 (100 μM) treatment allows normal DSB repair in HR-defective ATMi-treated or HSC62 (BRCA2-defective) cells[1]. RAD51 foci did not form following exo- or endo-inhibitor treatment (mirin or PFM01) in 1BR3 (WT) and HSC62 (BRCA2-defective) cells[1]. PFM01 (100 μM) enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells[1]. PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells[1]. |
Molecular Weight | 293.4 |
Formula | C14H15NO2S2 |
CAS No. | 1558598-41-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 4 mg/mL (13.63 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PFM01 1558598-41-6 Others Inhibitor derivative MRE11 PFM-01 NHEJ Mirin DSB endonuclease N-alkylated PFM 01 inhibit inhibitor