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BI-671800

🥰Excellent
Catalog No. T14565Cas No. 1093108-50-9
Alias Cmpd A, AP-761

BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2].

BI-671800

BI-671800

🥰Excellent
Purity: 99.19%
Catalog No. T14565Alias Cmpd A, AP-761Cas No. 1093108-50-9
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2].
Pack SizePriceAvailabilityQuantity
1 mg$53In Stock
5 mg$133In Stock
10 mg$218In Stock
25 mg$392In Stock
50 mg$557In Stock
100 mg$756In Stock
200 mg$987In Stock
1 mL x 10 mM (in DMSO)$147In Stock
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Purity:99.19%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2].
Targets&IC50
CRTH2 (human):4.5 nM (in CRTH2 transfected cells), CRTH2 (mouse):3.7 nM (in CRTH2 transfected cells)
In vitro
BI-671800 (compound A) is a potent small-molecule antagonist with low nanomolar potency against human or mouse CRTH2 in transfected cells[1].
In vivo
BI-671800 (compound A, 0.1-10 mg/kg, i.g.) significantly inhibits AHR in mice[1] and effectively prevents edema formation, reduces inflammatory infiltrate, and alleviates skin pathology observed in drug vehicle-treated animals[3].
SynonymsCmpd A, AP-761
Chemical Properties
Molecular Weight501.5
FormulaC25H26F3N5O3
Cas No.1093108-50-9
SmilesCN(C)c1nc(Cc2ccc(NC(=O)c3ccc(cc3)C(F)(F)F)cc2)nc(N(C)C)c1CC(O)=O
Relative Density.1.351 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 130 mg/mL (259.22 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9940 mL9.9701 mL19.9402 mL99.7009 mL
5 mM0.3988 mL1.9940 mL3.9880 mL19.9402 mL
10 mM0.1994 mL0.9970 mL1.9940 mL9.9701 mL
20 mM0.0997 mL0.4985 mL0.9970 mL4.9850 mL
50 mM0.0399 mL0.1994 mL0.3988 mL1.9940 mL
100 mM0.0199 mL0.0997 mL0.1994 mL0.9970 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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Keywords

ProstaglandinReceptorProstaglandin ReceptormCRTH2InhibitorinhibithCRTH2CRTh2 (DP2) receptorBI-671800BI671800BI 671800AP761AP 761
Related Tags: buy BI-671800 | purchase BI-671800 | BI-671800 cost | order BI-671800 | BI-671800 chemical structure | BI-671800 in vivo | BI-671800 in vitro | BI-671800 formula | BI-671800 molecular weight
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