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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1438 | Beta-Amyrin acetate | Antioxidant , HMG-CoA Reductase , Epoxide Hydrolase , Antifungal | |
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities. | |||
TN6909 | Polyporusterone B | (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one | Others |
Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) is a triterpene carboxylic aci... | |||
TN1256 | 3-O-Acetyl-16α-hydroxytrametenolic acid | 3-O-Acetyl-16 alpha-hydroxytrametenolic acid | Immunology/Inflammation related |
3-O-Acetyl-16α-hydroxytrametenolic acid has inhibitory activities against AAPH-induced hemolysis of red blood cells, it shows a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation... | |||
T76702 | Sutimlimab | Complement System | |
Sutimlimab is a novel monoclonal antibody targeting complement protein C1. Sutimlimab is commonly used as a C1 inhibitor to treat cold agglutina-associated hemolysis. | |||
TN1125 | Neonuezhenide | Antioxidant | |
Neonuezhenide is a phenolic compound isolated from Ligustrum officinale, which has strong antioxidant effects on free radical-induced hemolysis of red blood cells. | |||
TN1369 | Alloimperatorin | Prangenidin | Others |
Alloimperatorin (Prangenidin) exhibits in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration. It photosensitizes efficient... | |||
TN6908 | Polyporusterone A | (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one | |
Polyporusterone A is a triterpene carboxylic acid derived from the substrates of P. umbellatus.Polyporusterone A inhibits free radical-induced erythrocyte cleavage (hemolysis), and can be used in studies of hair regenera... | |||
T39520 | Vamifeport | VIT-2763 | Ferroptosis |
Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inf... | |||
T76831 | Tesidolumab | LFG316 | Complement System |
Tesidolumab (LFG316) is a fully human IgG1/λ anti-C5 monoclonal antibody. Tesidolumab (LFG316) has an inhibitory effect on crovalimab and C5, blocking the cutting of C5 and preventing the subsequent formation of membrane... | |||
TN1742 | Homovanillyl alcohol | TNF , Drug Metabolite | |
Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homovanillyl alcohol displays high scavenging activities, it pr... | |||
T3895 | Polyphyllin I | Apoptosis , Akt , JNK , PDK , mTOR , Autophagy | |
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha... | |||
T36766 | Palmitoylcholine (chloride) | ||
Palmitoylcholine is an acyl choline.1It inhibits protein kinase C activity when used at a concentration of 100 μM.2Palmitoylcholine induces hemolysis in rat erythrocytes.3Plasma levels of palmitoylcholine are decreased i... | |||
T70891 | Pyridoxatin | ||
Pyridoxatin is a fungal metabolite that inhibits production of thiobarbituric acid reactive substance (TBARS). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH and is active against C. albicans. | |||
T62020 | Pelecopan | ||
Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D (IC50= 14.3 nM). Pelecopan can prevent both intravascular and extravascular hemolysis in PNH. | |||
T83748 | RW4 TFA | (RW)4-NH2,Arg-Trp-Arg-Trp-Arg-Trp-Arg-Trp-NH2 | |
RW4, an antimicrobial peptide, exhibits activity against E. coli and S. aureus, with IC50 values of 9.6 and 5.1 µM, respectively. Additionally, it induces hemolysis of isolated ovine erythrocytes. | |||
TN1728 | Hellebrigenin | PARP , Akt , CDK | |
Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Hellebrigenin exhibites moderate to strong activity against ... | |||
T83747 | RW3 TFA | (RW)3-NH2,Arg-Trp-Arg-Trp-Arg-Trp-NH2 | |
RW3, an antimicrobial peptide, exhibits activity against E. coli and S. aureus with IC50 values of 16 µM and 8 µM, respectively. Additionally, it induces hemolysis in isolated ovine erythrocytes. | |||
T83746 | RW2 TFA | (RW)2-NH2,Arg-Trp-Arg-Trp-NH2 | |
RW2, an antimicrobial peptide, demonstrates activity against E. coli and S. aureus, with IC50 values of 730 µM and 210 µM, respectively. Additionally, it induces hemolysis in isolated ovine erythrocytes. | |||
T69589 | PX-316 | ||
PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor act... | |||
T77121 | Pozelimab | ||
Pozelimab (REGN3918), a fully human IgG4 monoclonal antibody, is designed to target and bind with high affinity to both C5 and its variants, effectively inhibiting complement-mediated hemolysis. It holds potential for re... |