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Polyphyllin I

Catalog No. T3895   CAS 50773-41-6

Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.

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Polyphyllin I Chemical Structure
Polyphyllin I, CAS 50773-41-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 52.00
10 mg In stock $ 89.00
25 mg In stock $ 153.00
50 mg In stock $ 238.00
100 mg In stock $ 397.00
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Purity: 99.36%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
Source
Molecular Weight 855.02
Formula C44H70O16
CAS No. 50773-41-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 117 mM

TargetMolReferences and Literature

1. Wu L,et al. Polyphyllin D induces apoptosis in K562/A02 cells through G2/M phase arrest.Wu L1, Li Q, Liu Y.J Pharm Pharmacol. 2014 May;66(5):713-21. 2. Yu Q,et al. Polyphyllin D induces apoptosis in U87 human glioma cells through the c-Jun NH2-terminal kinase pathway. J Med Food. 2014 Sep;17(9):1036-42.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Miao medicine Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Prostate Cancer Compound Library Anti-Tumor Natural Product Library Angiogenesis related Compound Library Anti-Pancreatic Cancer Compound Library Glycolysis Compound Library PI3K-AKT-mTOR Compound Library Anti-Breast Cancer Compound Library

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Keywords

Polyphyllin I 50773-41-6 Apoptosis Autophagy Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Akt JNK PDK mTOR PDK-1 Protein kinase B PKB inhibit Mammalian target of Rapamycin Inhibitor inhibitor

 

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