hematopoietic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22223	3PO		Glucokinase , Autophagy
	3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM). It suppresses glucose uptake, and decrea...		Glucokinase , Autophagy
T2121	SW033291		Dehydrogenase
	SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.		Dehydrogenase
T11438	GNE-1858		Others , MAPK
	GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).		Others , MAPK
TN2883	3',4'-Dimethoxyflavone		Others , PARP
	3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities.		Others , PARP
T69730	F092 inhibitor
	F092 inhibitor, also called Prostaglandin D synthase (hematopoietic-type) inhibitor F092, is an inhibitor of hematopoietic-type prostaglandin D synthase (H-PGDS).
T1776L	Plerixafor octahydrochloride	JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl	Virus Protease , HIV Protease , CXCR
	Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow a...		Virus Protease , HIV Protease , CXCR
T3590	NSC23005		CDK
	NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).		CDK
T8883	Pizuglanstat		Others , Prostaglandin Receptor
	Pizuglanstat is a hematopoietic prostaglandin synthase inhibitor.		Others , Prostaglandin Receptor
T24580	P18IN003	P18IN 003,P18IN-003	CDK
	P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of hematopoietic stem cells.		CDK
T7948	HPGDS inhibitor 2	GSK-2894631A	PGE Synthase
	HPGDS inhibitor 2 (GSK-2894631A) is a potent, selective hematopoietic prostaglandin D synthase (h-pgds) inhibitor, IC50 = 9.9 nm.		PGE Synthase
T16699	PYZD-4409		Others , E1/E2/E3 Enzyme
	PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.		Others , E1/E2/E3 Enzyme
T3589	NSC23005 Sodium		CDK
	NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.		CDK
T1804	HPGDS inhibitor 1	HPGDS-inhibitor-1	PGE Synthase
	HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.		PGE Synthase
T21785	AG957		Bcr-Abl
	Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].		Bcr-Abl
T60081	BV02	2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid	Others
	BV02 is an inhibitor of 14-3-3 protein-protein interactions and can be used in studies about the treatment of chronic myeloid leukemia. BV02 disrupts hematopoietic cells expressing the IM-resistant T315I mutation and the...		Others
T8836	CY5-SE triethylamine salt	Fluorolink Cy5 triethanolamine salt,Cy5-SE (triethylamine salt)	Others
	CY5-SE triethylamine salt (Fluorolink Cy5 triethanolamine salt) is a hydrophilic amine-reactive fluorescent probe. It displays excitation/emission maxima of 646/662 nm, respectively. Cy5-SE-conjugated ligands have been u...		Others
T11053	DJ001		Phosphatase
	DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase σ (PTPσ) inhibitor with IC50 of 1.43 μM. DJ001 promotes the regeneration of hematopoietic stem cells.		Phosphatase
T9017	HPK1-IN-2	Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2,HPK1-IN-2	Others , FLT , Src
	HPK1-IN-2 (Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2) is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1; IC50<0.05 μΜ). It also...		Others , FLT , Src
T76870	Narsoplimab	OMS 721	SARS-CoV
	Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody, a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 and prevents lectin pathway ac...		SARS-CoV
T22070	DBIBB		LPA Receptor
	DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of acute radiation syndrome caused by high intensity gamma ra...		LPA Receptor