Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase σ (PTPσ) inhibitor with IC50 of 1.43 μM. DJ001 promotes the regeneration of hematopoietic stem cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 455.00 | |
25 mg | In stock | $ 753.00 | |
50 mg | In stock | $ 1,060.00 | |
100 mg | In stock | $ 1,430.00 | |
500 mg | In stock | $ 2,860.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 318.00 |
Description | DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase σ (PTPσ) inhibitor with IC50 of 1.43 μM. DJ001 promotes the regeneration of hematopoietic stem cells. |
Targets&IC50 | PTPσ:1.43 μM |
In vitro | Compared with control culture, DJ001 (5-1000 ng/mL; 3-7 days; BM KSL cells) treatment can increase the percentage and number of BM KSL cells in culture. DJ001 treatment also significantly increased the number of colony forming cells (CFC) in BM KSL cells cultured for 3 days. The BM KSL cells were irradiated with 300 cGy and placed in a medium containing 1 μg/mL DJ001 and without 1 μg/mL DJ001 (containing 20 μng/mL thrombopoietin, 100 μng/mL stem cell factor (SCF), 50 μng/mL Flt3 Body, TSF). 3 days. Compared with control culture, DJ001 treatment can improve the recovery rate of BM CFC and multipotent colony forming unit-granulocyte-like erythrocyte mononuclear megakaryocyte (CFU-GEMM) colonies[1]. |
In vivo | DJ001 inhibits radiation-induced HSC apoptosis by activating RhoGTPase, RAC1 and inducing BCL-XL. DJ001 (5 μg/kg; subcutaneous injection; duration 24 hours; female C57BL/6 mice) significantly reduced the percentage of apoptotic BM KSL cells in C57BL/6 mice 24h after 500°cGy TBI[1]. |
Molecular Weight | 268.27 |
Formula | C15H12N2O3 |
CAS No. | 2161305-12-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225 mg/mL (838.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
DJ001 2161305-12-8 Metabolism Phosphatase DJ 001 DJ-001 inhibitor inhibit