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HPGDS inhibitor 1

Catalog No. T1804 CAS 1033836-12-2

Synonyms: HPGDS-inhibitor-1

HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.

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HPGDS inhibitor 1, CAS 1033836-12-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.
Targets&IC50	HPGDS:0.7 nM.
Kinase Assay	Kinetic characterization of Abl inhibition: The ATP/NADH-coupled assay system in a 96-well format is used to determine the initial velocity of Abl tyrosine kinase catalyzed peptide phosphorylation. The reaction mixture contained 20 mM Tris-HCl, (pH 8.0), 50 mM NaCl, 10 mM MgCl2, 2 mM PEP [2-(Phosphonooxy)- 2-propenoic acid) and 20 μg Abl peptide substrate (EAIYAAPFAKKK), fixed or varied (to determine inhibitor kinetic parameters) concentration of inhibitor applied, 1/50 of the final reaction mixture volume of PK/LDH enzyme (pyruvate kinase/lactic dehydrogenase enzymes from rabbit muscle), 160 μM NADH, 0.16 μM Abl, and ATP added last to start the reaction. Absorbance data are collected every 20s at 340 nm using a SpectraMax M5 Microplate Reader.

Synonyms	HPGDS-inhibitor-1
Molecular Weight	381.375
Formula	C19H19F4N3O
CAS No.	1033836-12-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chris P. Carron, et al. ACS Med. Chem. Lett., 2010, 1 (2), pp 59-63

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library Fluorochemical Library Nonsteroidal Anti-Inflammatory Compound Library Target-Focused Phenotypic Screening Library Bioactive Compound Library

Related Products

Related compounds with same targets

HPGDS inhibitor 2 Suprofen CAFESTOL ETHYL CAFFEATE Sinensetin Dehydroevodiamine hPGDS-IN-1 AT-56

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Keywords

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