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HPGDS inhibitor 1

HPGDS inhibitor 1
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HPGDS inhibitor 1

Catalog No. T1804Cas No. 1033836-12-2
HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.
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Pack SizePriceAvailabilityQuantity
1 mg$88In Stock
2 mg$129In Stock
5 mg$205In Stock
10 mg$368In Stock
25 mg$618In Stock
50 mg$883In Stock
100 mg$1,190In Stock
500 mg$2,420In Stock
1 mL x 10 mM (in DMSO)$220In Stock
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Product Introduction

HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.
Kinase Assay
Kinetic characterization of Abl inhibition: The ATP/NADH-coupled assay system in a 96-well format is used to determine the initial velocity of Abl tyrosine kinase catalyzed peptide phosphorylation. The reaction mixture contained 20 mM Tris-HCl, (pH 8.0), 50 mM NaCl, 10 mM MgCl2, 2 mM PEP [2-(Phosphonooxy)- 2-propenoic acid) and 20 μg Abl peptide substrate (EAIYAAPFAKKK), fixed or varied (to determine inhibitor kinetic parameters) concentration of inhibitor applied, 1/50 of the final reaction mixture volume of PK/LDH enzyme (pyruvate kinase/lactic dehydrogenase enzymes from rabbit muscle), 160 μM NADH, 0.16 μM Abl, and ATP added last to start the reaction. Absorbance data are collected every 20s at 340 nm using a SpectraMax M5 Microplate Reader.
Chemical Properties
Molecular Weight381.37
Cas No.1033836-12-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 55 mg/mL (144.22 mM)
Solution Preparation Table
1 mM2.6221 mL13.1106 mL26.2213 mL131.1063 mL
5 mM0.5244 mL2.6221 mL5.2443 mL26.2213 mL
10 mM0.2622 mL1.3111 mL2.6221 mL13.1106 mL
20 mM0.1311 mL0.6555 mL1.3111 mL6.5553 mL
50 mM0.0524 mL0.2622 mL0.5244 mL2.6221 mL
100 mM0.0262 mL0.1311 mL0.2622 mL1.3111 mL


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