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NSC23005

Name: NSC23005
Brand: TargetMol
SKU: T3590
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3590Cas No. 6314-70-1

NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).

NSC23005

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Purity: 99.97%

Catalog No. T3590Cas No. 6314-70-1

NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$176	In Stock	In Stock
50 mg	$283	In Stock	In Stock
100 mg	$455	-	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

NSC23005 AI Summary

NSC23005 demonstrates bioactivity in several assays, acting as an inhibitor of Anthrax Lethal Toxin Internalization with a potency of 5011.9 nM, an inhibitor of AmpC Beta-Lactamase with a potency of 44668.4 nM, and an inhibitor of Chronic Active B-Cell Receptor Signaling with a potency of 3162.3 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).

Chemical Properties

Molecular Weight	283.34
Formula	C₁₃H₁₇NO₄S
Cas No.	6314-70-1
Smiles	OC(=O)C1=CC=C(C=C1)S(=O)(=O)NC1CCCCC1
Relative Density.	1.36g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (158.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5293 mL	17.6466 mL	35.2933 mL	176.4664 mL
5 mM	0.7059 mL	3.5293 mL	7.0587 mL	35.2933 mL
10 mM	0.3529 mL	1.7647 mL	3.5293 mL	17.6466 mL
20 mM	0.1765 mL	0.8823 mL	1.7647 mL	8.8233 mL
50 mM	0.0706 mL	0.3529 mL	0.7059 mL	3.5293 mL
100 mM	0.0353 mL	0.1765 mL	0.3529 mL	1.7647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc