hematologic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6055	Quisinostat	JNJ-26481585	Apoptosis , HDAC , Autophagy
	Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against...		Apoptosis , HDAC , Autophagy
T12477	Uzansertib phosphate	INCB053914 phosphate	Pim
	Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively).		Pim
T6079	NVP-ADW742	ADW742,ADW,GSK 552602A	Apoptosis , IGF-1R
	NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.		Apoptosis , IGF-1R
T6865	Quisinostat dihydrochloride	Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl	Apoptosis , HDAC , Autophagy
	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g...		Apoptosis , HDAC , Autophagy
T12574	PTC299	Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate	VEGFR , Dehydrogenase
	PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at t...		VEGFR , Dehydrogenase
T1601	Lomustine	CCNU,NSC 79037	Apoptosis , Others , DNA Alkylator/Crosslinker , DNA Alkylation , Autophagy
	Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
T10436	AZD4573		CDK
	AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.		CDK
T17028	Tefinostat	CHR-2845	HDAC
	Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1).Tefino...		HDAC
T3S0209	Vincristine		ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR
	Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hemato...		ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR
T77385	Idactamab	INT-001
	Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2.
T25364	Efegatran	LY 294468,LY294468,LY-294468
	Efegatran is a hematologic agent and platelet aggregation inhibitor.
T20798	Fluindione	LM123,LM 123,LM-123
	Fluindione is a hematologic drug.
T27558	HT1042	HT 1042,HT-1042
	HT1042 is an inhibitor of the β5i component of the 20S proteasome complex, it is used to aid in the treatment of inflammatory diseases, autoimmune and hematologic malignancies.
T11544	HDACs/mTOR Inhibitor 1		HDAC
	HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1.2 nM, and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα).		HDAC
T39090	Uzansertib	INCB053914
	Uzansertib (INCB053914) is a potent ATP-competitive pan-PIM kinase inhibitor. It exhibits exceptional inhibitory activity against PIM1, PIM2, and PIM3 with IC50 values of 0.24 nM, 30 nM, and 0.12 nM, respectively. Furthe...
T38778	DB2115 tertahydrochloride	DB2115 tertahydrochloride
	DB2115 (tertahydrochloride) is a powerful inhibitor of the myeloid master regulator PU.1. With significant potential in cancer research, particularly hematologic cancers like leukemia, as well as other conditions linked ...
T63497	PI3Kδ/γ-IN-1
	PI3Kδ/γ-IN-1 is a selective and effective inhibitor of PI3Kδ/γ that can be used in the treatment of hematologic malignancies.
T81461	Pidilizumab	CT-011,MDV9300	PD-1/PD-L1
	Pidilizumab (CT-011), a humanized IgG1κ anti-PD-1 monoclonal antibody, serves as a DLL1 antagonist with potential applications in researching hematologic malignancies [1].		PD-1/PD-L1
T38857	SBP-0636457	SBI-0636457,SB1-0636457,SBP-0636457
	SBP-0636457 (SB1-0636457) is a SMAC mimetic and an inhibitor of inhibitor of apoptosis (IAP) proteins. It specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM. SBP-0636457 holds potential for ...
T60706	LP-284
	LP-284 kills solid tumours. LP-284 is a potent DNA alkylating agent that can be used in the hematologic cancers studies with compromised DNA repair, for example, mantle cell lymphoma (MCL) [1] [2].