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HDACs/mTOR Inhibitor 1

Catalog No. T11544 CAS 2271413-06-8

<a href="/target/HDAC" style="display: inline; color: #c13a36">HDAC</a>s/<a href="/target/mTOR" style="display: inline; color: #c13a36">mTOR</a> Inhibitor 1 is a dual <a href="/target/HDAC" style="display: inline; color: #c13a36">HDAC</a>s and mammalian target of Rapamycin (<a href="/target/mTOR" style="display: inline; color: #c13a36">mTOR</a>) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1.2 nM, and >500 nM for <a href="/target/HDAC" style="display: inline; color: #c13a36">HDAC</a>1, <a href="/target/HDAC" style="display: inline; color: #c13a36">HDAC</a>6, <a href="/target/mTOR" style="display: inline; color: #c13a36">mTOR</a> and <a href="/target/PI3K" style="display: inline; color: #c13a36">PI3K</a>α).

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HDACs/mTOR Inhibitor 1, CAS 2271413-06-8

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 970.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1.2 nM, and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα).
Targets&IC50	mTOR:1.2 nM, HDAC6:1.8 nM, HDAC1:0.19 nM
In vitro	HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cell apoptosis with low toxicity in vivo.

Molecular Weight	566.65
Formula	C28H38N8O5
CAS No.	2271413-06-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 32.5 mg/mL (57.35 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chen Y, et al. Discovery of a Novel Dual Histone Deacetylases (HDACs) and Mammalian Target of Rapamycin (mTOR) Target Inhibitor as a Promising Strategy for Cancer Therapy. J Med Chem. 2019 Jan 10.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HDACs/mTOR Inhibitor 1 2271413-06-8 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Inhibitor inhibitor inhibit

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