store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1).Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 118.00 | |
5 mg | In stock | $ 291.00 | |
10 mg | In stock | $ 432.00 | |
25 mg | In stock | $ 715.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,360.00 |
Description | Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1).Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies. |
In vitro | Tefinostat (1-4 nM; AML cell lines) demonstrates efficacy in AML cell lines, including HL60 (M2 FAB type), MV411 (M4, FLT3-ITD), OCIAML3 (M4 NPM1mut), and THP1 (M5), with EC50 values of 2.3 μM, 57 nM, 110 nM, and 560 nM, respectively. |
Synonyms | CHR-2845 |
Molecular Weight | 495.61 |
Formula | C28H37N3O5 |
CAS No. | 914382-60-8 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (181.59 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Tefinostat 914382-60-8 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC CHR 2845 CHR-2845 CHR2845 inhibitor inhibit