function-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13273	UT-34		Androgen Receptor
	UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...		Androgen Receptor
T17143	Toyocamycin	Vengicide	Apoptosis , Others , IRE1 , Antibiotic , Antifungal
	Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.		Apoptosis , Others , IRE1 , Antibiotic , Antifungal
T14676	BMS-688521		Integrin
	BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.		Integrin
T3977	Lifitegrast	SHP-606,SAR 1118	Integrin
	Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.		Integrin
T27084	Crisdesalazine	AAD2004,AAD 2004,AAD-2004	Prostaglandin Receptor
	Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and incre...		Prostaglandin Receptor
T14969	CINPA1	CINPA-1,CINPA 1	Others
	CINPA1 (CINPA 1) is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function.		Others
T21781	A-286982		Integrin
	A 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1.		Integrin
T12783	RWJ 50271		Integrin
	RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 cells).		Integrin
T8870	1-(4-methansulfinylphenyl)ethanone		Ras
	The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.		Ras
T0038	Doxapram hydrochloride hydrate	Doxapram hydrochloride monohydrate,Doxapram HCl	Potassium Channel
	Doxapram hydrochloride hydrate (Doxapram HCl) effectively inhibits the function of TASK-1, TASK-3, and TASK-1/TASK-3 heterodimeric channels, displaying EC50 values of 410 nM, 37 μM, and 9 μM, respectively.		Potassium Channel
T9179	CLP-3094	2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE	Androgen Receptor
	CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) is a potent androgen receptor BF3 (binding function 3) inhibitor. BF3-IN-1 inhibits AR transcriptional activity with IC50 of 4 μM. CLP-3094 is a selective and potent GP...		Androgen Receptor
TN4661	Nodosin		IL Receptor , Autophagy
	Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transp...		IL Receptor , Autophagy
T22980	MIRA-1	p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor	DNA/RNA Synthesis , p53
	MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.		DNA/RNA Synthesis , p53
T50047	1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride		Others
	1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride is a cholinergic agent that inhibits choline metabolism, which leads to increased levels of acetylcholine in the brain, which in turn enhances cognitive ...		Others
T27710	K6PC-5	K6PC5,K6PC 5	S1P Receptor
	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated ...		S1P Receptor
T2650	MK-8245		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
	MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
T37042	SCH529074	SCH 529074	p53
	SCH529074 is a selective activator of p53 (Ki = 1 μM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53.		p53
T4414	Eprenetapopt	APR-246,PRIMA-1Met	Apoptosis , Others , Ferroptosis , p53 , Autophagy
	Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c...		Apoptosis , Others , Ferroptosis , p53 , Autophagy
T76687	Ibalizumab	TNX-355,TMB-355	HIV Protease
	Ibalizumab(TMB-355) is a humanized IgG4 monoclonal antibody that acts as a CD4 receptor inhibitor, blocking the entry of HIV-1 into cells by binding to the CD4 receptor.Ibalizumab has anti-HIV-1 infectious activity and m...		HIV Protease
T6981	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid	Nudifloric Acid	Others
	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (Nudifloric Acid) is from Cordyceps bassiana. Nudifloric Acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function.		Others