dyslipidemia — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7992	4-Hydroxyflavanone		NO Synthase
	4-Hydroxyflavanone is a natural product, shows full vasorelaxing effects		NO Synthase
T9766	GW590735		PPAR
	GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used in dyslipidemia studies.		PPAR
T4628	Seladelpar	MBX 8025	PPAR
	Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.		PPAR
T27719	KD-026	SLx 4090,SLx4090,KD026,SLx-4090	CETP
	KD-026 (SLx 4090), a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies.		CETP
T3324	Lycorine	Galanthidine,Narcissine,Amarylline,Belamarine,Licorine	Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase
	Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T31083	CP-868388 free base	CP868388,CP 868388,(-)-CP-868388,UNII-999KY5ZIGB,CP-868388	PPAR
	CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.		PPAR
T77784	WAY-297848		Glucokinase
	WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.		Glucokinase
T20950	MK-8245 analog	MK-8245-analog,MK 8245 analog	Others
	MK-8245 analog is an analog of MK-8245 which is a liver-targeted Inhibitor of Stearoyl-CoA Desaturase (SCD). It is useful for the Treatment of Dyslipidemia and Diabetes.		Others
T27439	GS-9667	CVT-3619,CVT 3619	Adenosine Receptor
	GS-9667, a selective and partial agonist of the A(1) adenosine receptor (AR), represents an effective therapy for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA).		Adenosine Receptor
T5S2178	Fargesin	(+/-)-Fargesin	Adrenergic Receptor
	1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating...		Adrenergic Receptor
T35868	BCAT-IN-2		Others
	BCAT-IN-2 is an orally active and selective inhibitor of mitochondrial branched-chain aminotransferase (BCATm), inhibits BCATm and BCATc, and is used in obesity and dyslipidemia.		Others
T27509	GW-493838	GW 493838X,GW 493838,GW493838,GW493838X,GW-493838X	Adenosine Receptor
	GW-493838 is a potent adenosine A1A receptor agonist for the treatment of dyslipidemia and neuropathic pain, with analgesic effects on post-herpetic neuralgia or peripheral nerve damage caused by trauma or surgery.		Adenosine Receptor
T21587	Muraglitazar	Pargluva,BMS-298585	PPAR
	Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM r...		PPAR
T38683	SCD1 inhibitor-3	SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a	Dehydrogenase
	SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety. SCD1 inhibitor-3 demonstrates strong potential for research in metabolic diseases, including obesit...		Dehydrogenase
T3685	SR9009	Stenabolic,REV-ERB Agonist II	Autophagy
	SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during...		Autophagy
T27706	K-111	BM170744,BM 170744,BM-170744,K111
	K-111 is a PPAR alpha agonist. K-111 improves insulin resistance, reducing bodyweight, and ameliorating atherogenic dyslipidemia.
T27749	KRP-297	KRP297,MK-0767,L410198,L 410198
	KRP297 is a PPAR agonist potentially for the treatment of type 2 diabetes and dyslipidemia.
T33415	MK 0767	MK0767,MK-0767
	MK 0767 is a dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist that has been investigated as a potential treatment for type 2 diabetes and dyslipidemia.
T15264	Exicorilant	CORT 125281	Others
	Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.		Others
T71560	Atorvastatin magnesium trihydrate
	Atorvastatin magnesium trihydrate is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase...