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KD-026

Catalog No. T27719 CAS 913541-47-6

Synonyms: SLx4090, SLx-4090, KD 026, SLx 4090, KD026

KD-026, a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies.

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KD-026, CAS 913541-47-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KD-026, a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies.
Targets&IC50	apolipoprotein B:9.6 nM, MTP:8.0 nM
In vitro	KD-026 shows inhibitory effect against apolipoprotein B (IC50 = 9.6 nM) but no effect on apolipoprotein A1 secretion in Caco-2 cells[1].
In vivo	In rats, KD-026 (30 mg/kg) reduced postprandial lipids by 50% (ED50 = 7 mg/kg)[1].

Synonyms	SLx4090, SLx-4090, KD 026, SLx 4090, KD026
Molecular Weight	546.54
Formula	C31H25F3N2O4
CAS No.	913541-47-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 55 mg/ml (100.63 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Enoch Kim, et al. A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85.

Related Products

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Lomitapide Evacetrapib Dalcetrapib Obicetrapib KD-026 Lomitapide Mesylate Torcetrapib NAMI-A

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KD-026 913541-47-6 代谢 CETP KD 026 microsomal triglyceride transfer protein MTP inhibitor KD026 SLx 4090 inhibit SLx-4090 Inhibitor enterocytic-specific dyslipidemia SLx4090 inhibitor

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