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KD-026

Name: KD-026
Brand: TargetMol
SKU: T27719
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27719Cas No. 913541-47-6

Alias SLx-4090, SLx4090, SLx 4090, KD026

KD-026 (SLx 4090), a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies.

KD-026

🥰Excellent

Purity: 99.74%

Catalog No. T27719Alias SLx-4090, SLx4090, SLx 4090, KD026Cas No. 913541-47-6

KD-026 (SLx 4090), a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies.

Pack Size	Price	Availability
1 mg	$74	In Stock
2 mg	$106	In Stock
5 mg	$173	In Stock
10 mg	$273	In Stock
25 mg	$467	In Stock
50 mg	$592	In Stock
100 mg	$816	In Stock
200 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$221	In Stock

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Purity:99.74%

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COA LCMS

Product Introduction

Bioactivity

Description	KD-026 (SLx 4090), a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies.
Targets&IC50	MTP:8.0 nM, ApoB:9.6 nM
In vitro	KD-026 shows inhibitory effect against apolipoprotein B (IC50 = 9.6 nM) but no effect on apolipoprotein A1 secretion in Caco-2 cells[1].
In vivo	In rats, KD-026 (30 mg/kg) reduced postprandial lipids by 50% (ED50 = 7 mg/kg)[1].
Synonyms	SLx-4090, SLx4090, SLx 4090, KD026

Chemical Properties

Molecular Weight	546.54
Formula	C₃₁H₂₅F₃N₂O₄
Cas No.	913541-47-6
Smiles	COc1cccc(C(=O)Nc2ccc3CN(CCc3c2)C(=O)Oc2ccccc2)c1-c1ccc(cc1)C(F)(F)F
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (100.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8297 mL	9.1485 mL	18.2969 mL	91.4846 mL
5 mM	0.3659 mL	1.8297 mL	3.6594 mL	18.2969 mL
10 mM	0.1830 mL	0.9148 mL	1.8297 mL	9.1485 mL
20 mM	0.0915 mL	0.4574 mL	0.9148 mL	4.5742 mL
50 mM	0.0366 mL	0.1830 mL	0.3659 mL	1.8297 mL
100 mM	0.0183 mL	0.0915 mL	0.1830 mL	0.9148 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc