store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 199.00 |
Description | CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia. |
Targets&IC50 | PPARγ (human):3.47 μM (Ki), PPARα (human):10.8 nM (Ki), SRC-1:4.7 nM (EC50), HepG2 cells:18 nM (EC50) |
In vitro | The compound CP-868388, at concentrations ranging from 0-1 mM, exhibits strong and dose-dependent recruitment of SRC-1, with an EC50 of 4.7 nM, as well as the PGC-1α peptide[1]. Additionally, CP-868388 demonstrates potent and selective transcriptional activation of PPARα, showing an EC50 of 18 nM in HepG2 cells[1]. |
In vivo | In male B6/CBF1J mice, treatment with CP-868388 (oral gavage; once daily; for 2 days) at doses ranging from 0-3 mg/kg results in a robust and highly significant decrease in circulating plasma triglycerides. The dose-dependent effect is observed, with the highest efficacy achieved at the 3.0 mg/kg dose, leading to a reduction of approximately 50% in triglyceride levels[1]. |
Synonyms | CP868388, CP 868388, (-)-CP-868388, UNII-999KY5ZIGB, CP-868388 |
Molecular Weight | 439.54 |
Formula | C26H33NO5 |
CAS No. | 702681-67-2 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (227.51 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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CP-868388 free base 702681-67-2 DNA Damage/DNA Repair Metabolism PPAR CP868388 CP 868388 free base CP 868388 (-)-CP-868388 UNII-999KY5ZIGB CP-868388 CP868388 free base inhibitor inhibit