drug — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4661	PKG drug G1		PKA
	PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.		PKA
T23757	Ascorbic acid, rutoside drug combination	Rutinoscorbin,Rutascorbin,Ruta C 60,Cerutin
	Ascorbic acid, rutoside drug combination is used for treating diabetic retinopathy.
T22334	FMOC-3VVD-OH		Others
	FMOC-3VVD-OH is an active chemical.		Others
T15058	DBCO-amine
	DBCO-amine is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis[1].
T15098	Deruxtecan		Others
	Deruxtecan is an ADC drug-linker conjugate consisting of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker for the synthesis of DS-8201 and U3-1402.		Others
T4346	SPDB		Others
	SPDB is a small fragment linked to DM4 conjugates. It conjugates to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.		Others
Fr13756	Isonicotinic acid		Endogenous Metabolite , Drug Metabolite
	Isonicotinic acid is a metabolite of Isoniazid.Isonicotinic acid is a useful isomer of nicotinic acid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the biotransformation also to be catalyzed by cyt...		Endogenous Metabolite , Drug Metabolite
T8547	DCBA		Drug Metabolite
	DCBA, an endogenous metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), is utilized to evaluate DEET exposure through its concentration levels in urine.		Drug Metabolite
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor
T17389	AMAS		Others
	AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing molecules.		Others
T13539	Allopurinol riboside		Others , Endogenous Metabolite , Parasite , Drug Metabolite
	Allopurinol riboside is a metabolite of allopurinol with potency against parasites. Allopurinol riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM.		Others , Endogenous Metabolite , Parasite , Drug Metabolite
T8115	Menthofuran		Others
	Menthofuran is a natural product.		Others
T15179	DTSSP Crosslinker		Others
	DTSSP Crosslinker is a cleavable ADC linker and can be used to synthesize antibody-drug conjugates (ADCs).		Others
T15176	DSS Crosslinker		Others
	DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).It is a homobifunctional crosslinker that is cell membrane permeable. DSS crosslinker has amine-reactive NHS esters a...		Others
TN4660	Niranthin		Anti-infection , HBV , PAFR , Topoisomerase
	Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. N...		Anti-infection , HBV , PAFR , Topoisomerase
T3540	IMR-1A		Gamma-secretase , Drug Metabolite
	IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.		Gamma-secretase , Drug Metabolite
T16218	N-Boc-PEG5-bromide		Others , PROTAC Linker
	N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].		Others , PROTAC Linker
T18723	Succinic anhydride		Others
	Succinic anhydride is a cyclic anhydride. Succinic anhydride acts as a nonclaevable ADC linker. Succinic anhydride can react with compound 4 to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.		Others
T13621	CNDAC hydrochloride		Nucleoside Antimetabolite/Analog , Others , Drug Metabolite
	CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.		Nucleoside Antimetabolite/Analog , Others , Drug Metabolite
T0150	Hydroxyhexamide	(±)-Hydroxyhexamid	Potassium Channel , Drug Metabolite
	Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.		Potassium Channel , Drug Metabolite