Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 369.00 | |
25 mg | In stock | $ 622.00 | |
50 mg | In stock | $ 885.00 | |
100 mg | In stock | $ 1,190.00 | |
500 mg | In stock | $ 2,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 252.00 |
Description | IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. |
Targets&IC50 | IMR-1:6 μMol/L. |
In vitro | IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth. A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO). |
In vivo | The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish. |
Molecular Weight | 325.36 |
Formula | C13H11NO5S2 |
CAS No. | 331862-41-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.23 mg/mL (13 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IMR-1A 331862-41-0 Metabolism Neuroscience Proteases/Proteasome Stem Cells Drug Metabolite Gamma-secretase Notch Inhibitor inhibit IMR1A IMR 1A inhibitor