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Niranthin

Catalog No. TN4660 CAS 50656-77-4

Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions.

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Niranthin, CAS 50656-77-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 198.00
5 mg	In stock	$ 520.00
10 mg	In stock	$ 748.00
25 mg	In stock	$ 1,150.00
50 mg	In stock	$ 1,530.00
100 mg	In stock	$ 1,980.00
1 mL * 10 mM (in DMSO)	In stock	$ 530.00

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Purity: 99.8%

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Description	Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions.
In vitro	This study was designed to evaluate the anti-hepatitis B virus activity of Niranthin using HepG2.2.15 cells and duck hepatitis B virus (DHBV) infected ducks as in vitro and in vivo models. METHODS AND RESULTS:: Niranthin was isolated from Phyllanthus niruri L. (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hepatitis B virus activity was evaluated both in vitro and in vivo. The human HBV-transfected liver cell line HepG2.2.15 was used in vitro assay. And the in vivo anti-hepatitis B virus activity was evaluated on the expression of HBV replication, HBsAg, HBeAg, ALT and AST on day 0, 7, 14, 17 after Niranthin was dosed intragastricly (i.g.) once a day for 14 days at the dosages of 25, 50 and 100 mg/kg/day in the duck hepatitis B virus (DHBV) infected ducks. In the human HBV-transfected liver cell line HepG2.2.15, the secretion of HBsAg and HBeAg were significantly decreased after treatment with Niranthin for 144 h, with IC50 values for HBsAg of 15.6 μM, IC50 values for HBeAg of 25.1 μM. In DHBV-infected ducklings, Niranthin significantly reduced the serum DHBV DNA, HBsAg, HBeAg, ALT and AST. Furthermore, analysis of the liver pathological changes confirmed the hepatoprotective effect of Niranthin. CONCLUSIONS:The experimental data demonstrated that Niranthin exhibits anti-hepatitis B virus activity both in vitro and in vivo. values for HBsAg of 15.6 μM, IC50 values for HBeAg of 25.1 μM. In DHBV-infected ducklings, Niranthin significantly reduced the serum DHBV DNA, HBsAg, HBeAg, ALT and AST. Furthermore, analysis of the liver pathological changes confirmed the hepatoprotective effect of Niranthin. CONCLUSION: The experimental data demonstrated that Niranthin exhibits anti-hepatitis B virus activity both in vitro and in vivo.
Source	Natural Products > Euphorbiaceae > Phyllanthus

Molecular Weight	432.51
Formula	C24H32O7
CAS No.	50656-77-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (150.29 mM)

References and Literature

1. In vitro and in vivo anti-hepatitis B virus activities of the lignan niranthin isolated from Phyllanthus niruri L. J Ethnopharmacol. 2014 Sep 11;155(2):1061-7.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Traditional Chinese Medicine Monomer Library Antiparasitic Natural Product Library Membrane Protein-targeted Compound Library GPCR Compound Library Human Metabolite Library Anti-infective Natural Product Library Selected Plant-Sourced Compound Library Anti-Obesity Compound Library Anti-Viral Compound Library

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Keywords

Niranthin 50656-77-4 DNA Damage/DNA Repair GPCR/G Protein Microbiology/Virology Anti-infection HBV Topoisomerase PAFR inhibit anti-leishmanial agent leishmaniasis Parasite drug-resistant Inhibitor inhibitor

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