diffuse — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10096L	Voruciclib		CDK
	Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ...		CDK
T16040	Mepazine	Pecazine	Apoptosis , MALT
	Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.		Apoptosis , MALT
T3549	Avadomide	CC 122	Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
	Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.		Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
T1944	LDN-214117		ALK , TGF-beta/Smad
	LDN-214117 is a potent and selective ALK2 inhibitor.		ALK , TGF-beta/Smad
T14367	AZ1495		IRAK , CDK , Haspin Kinase
	AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu...		IRAK , CDK , Haspin Kinase
T5354	IRAK4-IN-7	CA-4948	IRAK
	IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.		IRAK
T5598	Cis-3-Hexenyl hexanoate		Others
	cis-3-Hexenyl hexanoate, existing in some fruit, has strong diffuse fruit aroma.		Others
T60008	BCL6-IN-6		BCL
	BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes.		BCL
T77135	Tafasitamab	MOR00208,XmAb5574,Tafasitamab-cxix	Apoptosis , Immunology/Inflammation related
	Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.		Apoptosis , Immunology/Inflammation related
T77367	Urelumab	BMS-663513,BMS-66513	Others
	Urelumab(BMS-66513) is a humanized IgG4 monoclonal antibody, often used as a CD137 agonist.Urelumab has potential antitumor activity, potentiating tumor cell killing by T-cells and natural killer cells, and enhancing the...		Others
T9969	EZM0414		Histone Methyltransferase
	EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay. EZM0414 can be used for the research of relapsed or refractory m...		Histone Methyltransferase
T19281L	Dihydroxyacetone phosphate hemimagnesium salt hydrate	Dihydroxyacetone phosphate hemimagnesium salt hydrate(57-04-5 free base)	Others
	Dihydroxyacetone phosphate hemimagnesium salt hydrate is also known as dihydroxyacetone phosphate or 3-hydroxy-2-oxopropyl phosphate. Dihydroxyacetone phosphate hemimagnesium salt hydrate is found in all organisms from b...		Others
T23409	FM4-64	SynaptoRedTM C2	Others
	FM4-64 (SynaptoRedTM C2) is a styryl dye that stains stably but does not fluoresce in aqueous solution.FM4-64 does not passively diffuse into the plasma membrane bilayer and must be actively transported across the membra...		Others
T76776	Emactuzumab	RO 5509554,RG 7155	c-Fms , TAM Receptor
	Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating fa...		c-Fms , TAM Receptor
T10529	BF-168		Others
	BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).		Others
T25400	EZH2-IN-3	EZH2 inhibitor 3,EZH2-inhibitor-3
	EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.
T20173	Noradrenaline tartrate	NSC 169106,NSC-169106,l-Noradrenaline d-bitartrate,NSC169106,Norepinephrine bitartrate
	Norepinephrine bitartrate is a precursor of epinephrine. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceru...
T40634	Perilla ketone
	Perilla ketone is a naturally occurring xenobiotic compound that undergoes activation by pulmonary P450 cytochrome enzymes within the lung. This activation leads to the manifestation of severe pulmonary damage and the de...
T76946	Zuberitamab
	Zuberitamab (HS006) is a monoclonal antibody targeting CD20, utilized in cancer research, notably in diffuse large B-cell lymphoma [1].
T40901	Aderbasib	INCB007839,INCB7839
	Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for...