Shopping Cart

Remove All
Your shopping cart is currently empty

Mepazine

Name: Mepazine
Brand: TargetMol
SKU: T16040
Price: 187 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16040Cas No. 60-89-9

Alias Pecazine

Mepazine (Pecazine) is a potent and selective inhibitor of MALT1, inhibiting GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM, respectively. Mepazine enhances apoptosis and impacts cell viability.

Mepazine

🥰Excellent

Purity: 99.92%

Catalog No. T16040Alias PecazineCas No. 60-89-9

Pack Size	Price	Availability
10 mg	$33	In Stock
25 mg	$55	In Stock
50 mg	$85	In Stock
100 mg	$118	In Stock
200 mg	$187	In Stock
500 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.92%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Mepazine (Pecazine) is a potent and selective inhibitor of MALT1, inhibiting GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM, respectively. Mepazine enhances apoptosis and impacts cell viability.
In vitro	Mepazine (5, 10, and 20 μM) decreases cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells[1].
In vivo	In female NSG mice with a murine DLBCL xenogeneic tumor model, Mepazine (16 mg/kg; i.p.) interferes with the growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10. Mepazine strongly impairs the expansion of OCI-Ly10 with daily administration[1].
Synonyms	Pecazine

Chemical Properties

Molecular Weight	310.46
Formula	C₁₉H₂₂N₂S
Cas No.	60-89-9
Smiles	CN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
Relative Density.	1.1252 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (80.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2210 mL	16.1051 mL	32.2103 mL	161.0513 mL
5 mM	0.6442 mL	3.2210 mL	6.4421 mL	32.2103 mL
10 mM	0.3221 mL	1.6105 mL	3.2210 mL	16.1051 mL
20 mM	0.1611 mL	0.8053 mL	1.6105 mL	8.0526 mL
50 mM	0.0644 mL	0.3221 mL	0.6442 mL	3.2210 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc