cytomegalovirus — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1068	Tricin		Others , CDK
	Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7.		Others , CDK
T9648	SIRT1-IN-1		Antiviral , Sirtuin
	SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM. SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity.		Antiviral , Sirtuin
T38514	PMEDAP		Others , HIV Protease
	PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP also has anti-murine cytomega...		Others , HIV Protease
T0718	Brivudine	Bromovinyldeoxyuridine,BVDU	Others , HSV
	Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster.		Others , HSV
T15235	Enocitabine		Nucleoside Antimetabolite/Analog , HCV Protease , DNA/RNA Synthesis
	Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and antiviral activities. Enocitabine is also a potent DNA replication inhibitor and a ...
T7659	Bisindolylmaleimide IV		Others , PKC
	Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)		Others , PKC
T14324	Artemisone	BAY 44-9585,Artemifone	Others , Parasite
	Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.		Others , Parasite
T2162	Maribavir	BW1263W94,GW257406X,Benzimidavir,1263W94	Others , HCV Protease
	Maribavir (GW257406X) is an orally available benzimidazole riboside compound with activity against cytomegalovirus (CMV). Maribavir is a selective ATP competitor of the viral UL97 kinase, which is involved in viral nucle...		Others , HCV Protease
T3342	Xanthohumol		Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV
	Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ...
T5396	Letermovir	AIC246,MK-8828	Others , HCV Protease
	Letermovir (AIC246) (AIC246) is a novel anti-CMV compound (EC50: about 5 nM in fibroblast cells). It targets the pUL56 subunit of the viral terminase complex.		Others , HCV Protease
T1533	Valganciclovir hydrochloride	Valganciclovir HCl,Valcyt,Valcyte	Others , Antiviral
	Valganciclovir hydrochloride (Valganciclovir HCl) is a hydrochloride salt form of valganciclovir, a prodrug form of ganciclovir, a nucleoside analog of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, v...		Others , Antiviral
T0220	Foscarnet sodium	Phosphonoformate	Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
	Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.		Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
TQ0095	Brincidofovir	CMX001,HDP-CDV	Others , Antiviral , HSV
	Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses.		Others , Antiviral , HSV
T6593	ML324		Histone Demethylase , Others , HSV
	ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).		Histone Demethylase , Others , HSV
T39477	Calcium trinatrium diethylenetriaminepentaacetic acid hydrate	Ca-DTPA trisodium salt hydrate	Others
	Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Ca-DTPA tris...		Others
T8972	FIT-039		Others , DNA/RNA Synthesis , CDK , HSV
	FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr...		Others , DNA/RNA Synthesis , CDK , HSV
T6244	Cidofovir	HPMPC,GS 0504,(S)-HPMPC	Others , DNA/RNA Synthesis
	Cidofovir ((S)-HPMPC) inhibits virus replication by specific inhibition of viral DNA synthesis.		Others , DNA/RNA Synthesis
T8736	Cidofovir dihydrate	HPMPC,(S)-HPMPC,GS 0504	Others
	Cidofovir dihydrate (HPMPC) is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. Cidofovir dihydrate is an ...		Others
T1591	Ancitabine hydrochloride	NSC 145668 HCl,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C	Others , DNA/RNA Synthesis , Autophagy
	Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytar...		Others , DNA/RNA Synthesis , Autophagy
T0964	Floxuridine	5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640	Apoptosis , Nucleoside Antimetabolite/Analog , Others , DNA/RNA Synthesis , Antibacterial , HSV
	Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.