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Floxuridine

Floxuridine
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
Catalog No. T0964Cas No. 50-91-9
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Purity:99.96%
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Floxuridine

Catalog No. T0964Cas No. 50-91-9
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$30In Stock
50 mg$38In Stock
100 mg$57In Stock
500 mg$197In Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Product Introduction

Bioactivity
Description
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
In vitro
Floxuridine exhibits higher affinity for PEPT1 than the corresponding 5'-O-mono amino acid ester prodrugs. [1] Floxuridine combined with Leucovorin results in synergistic inhibitory effects on growth of human T-lymphoblast leukemia cells. [2] Floxuridine significantly inhibits the uptake of both [(3)H]-inosine and [(3)H]-adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibits markedly decreased inhibition potency (10-30% of control). [3] Floxuridine inhibits cell proliferation by more than 50% relative to the untreated control cells at 36 days, the cell numbers still increases fourfold compared with the initial cell density. Floxuridine results in prolonged effects on the proliferation of human Tenon's capsule fibroblasts in vitro. [4] Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction. [5]
Alias5-Fluorouracil 2'-deoxyriboside, FUDR, Deoxyfluorouridine, NSC 27640
Chemical Properties
Molecular Weight246.19
FormulaC9H11FN2O5
Cas No.50-91-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 24.6 mg/mL (100 mM)
DMSO: 35 mg/mL (142.17 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM4.0619 mL20.3095 mL40.6190 mL203.0952 mL
5 mM0.8124 mL4.0619 mL8.1238 mL40.6190 mL
10 mM0.4062 mL2.0310 mL4.0619 mL20.3095 mL
20 mM0.2031 mL1.0155 mL2.0310 mL10.1548 mL
50 mM0.0812 mL0.4062 mL0.8124 mL4.0619 mL
100 mM0.0406 mL0.2031 mL0.4062 mL2.0310 mL

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