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Cidofovir dihydrate

Catalog No. T8736 CAS 149394-66-1

Synonyms: HPMPC, (S)-HPMPC, GS 0504

Cidofovir dihydrate (HPMPC) is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. Cidofovir dihydrate is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis- an infection of the retina of the eye in people with AIDS

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Cidofovir dihydrate, CAS 149394-66-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 75.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 192.00
100 mg	In stock	$ 287.00
200 mg	In stock	$ 431.00

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Purity: 99.97%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cidofovir dihydrate (HPMPC) is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. Cidofovir dihydrate is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis- an infection of the retina of the eye in people with AIDS
In vitro	Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]
In vivo	Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5]
Kinase Assay	EGFR kinase assays: In vitro inhibitory enzyme kinetic assays using recombinant EGFR L858R/T790M and WT protein and are performed using the ATP/NADH coupled assay system in a 96-well format. WZ4002 is added to determine its inhibitory effects.

Synonyms	HPMPC, (S)-HPMPC, GS 0504
Molecular Weight	315.22
Formula	C8H18N3O8P
CAS No.	149394-66-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

References and Literature

1. Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844. 2. Li SB, et al. Antiviral Res, 1990, 13(5), 237-252. 3. Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192. 4. De Clercq E, et al. Antimicrob Agents Chemother, 1991, 35(4), 701-706. 5. Redondo P, et al. Br J Dermatol, 2000, 143(4), 741-748.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library EMA Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Infection Compound Library Approved Drug Library DNA Damage & Repair Compound Library NO PAINS Compound Library Nucleotide Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Cidofovir dihydrate 149394-66-1 Others (S)-HPMPC dihydrate retinitis Apoptosis Cytomegalovirus antiviral HPMPC dihydrate GS 0504 dihydrate HPMPC Orthopoxvirus herpes GS-0504 inhibit (S)-HPMPC Inhibitor Cidofovir Dihydrate Cidofovir GS 0504 cancer Endogenous Metabolite GS0504 CMV DNA/RNA Synthesis inhibitor

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