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Brivudine

Catalog No. T0718 CAS 69304-47-8

Synonyms: Bromovinyldeoxyuridine, BVDU

Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster.

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Brivudine, CAS 69304-47-8

Pack Size	Availability	Price/USD
25 mg	In stock	$ 39.00
50 mg	In stock	$ 55.00
100 mg	In stock	$ 72.00
200 mg	In stock	$ 98.00
500 mg	In stock	$ 158.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.4%

Purity: 99.27%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster.
In vitro	Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases thereby inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus than reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2].
In vivo	At a dose of 125 mg once daily, brivudine has been shown to be superior to aciclovir with respect to reducing the period of new blister production and shortening the duration of post-herpetic neuralgia[1].

Synonyms	Bromovinyldeoxyuridine, BVDU
Molecular Weight	333.14
Formula	C11H13BrN2O5
CAS No.	69304-47-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 330 mg/mL

References and Literature

1. Rabasseda X, et al. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71. 2. Keam SJ, et al. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-COVID-19 Compound Library ReFRAME Related Library NO PAINS Compound Library Clinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Brivudine 69304-47-8 Microbiology/Virology Others HSV Cytomegalovirus CMV Inhibitor Bromovinyldeoxyuridine BVDU inhibit inhibitor

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