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Brivudine

Catalog No. T0718   CAS 69304-47-8
Synonyms: Bromovinyldeoxyuridine, BVDU

Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster.

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Brivudine Chemical Structure
Brivudine, CAS 69304-47-8
Pack Size Availability Price/USD Quantity
25 mg In stock $ 39.00
50 mg In stock $ 55.00
100 mg In stock $ 72.00
200 mg In stock $ 98.00
500 mg In stock $ 158.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 99.4%
Purity: 99.27%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster.
In vitro Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases thereby inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus than reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2].
In vivo At a dose of 125 mg once daily, brivudine has been shown to be superior to aciclovir with respect to reducing the period of new blister production and shortening the duration of post-herpetic neuralgia[1].
Synonyms Bromovinyldeoxyuridine, BVDU
Molecular Weight 333.14
Formula C11H13BrN2O5
CAS No. 69304-47-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 330 mg/mL

TargetMolReferences and Literature

1. Rabasseda X, et al. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71. 2. Keam SJ, et al. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Preclinical Compound Library ReFRAME Related Library Anti-Viral Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max

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Keywords

Brivudine 69304-47-8 Microbiology/Virology Others HSV Cytomegalovirus CMV Inhibitor Bromovinyldeoxyuridine BVDU inhibit inhibitor

 

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