clinical — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10096L	Voruciclib		CDK
	Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ...		CDK
T16483	PF-05105679		TRP/TRPV Channel
	PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.		TRP/TRPV Channel
T6349L	Sitafloxacin	DU6859,DU 6859,DU 6859A,Sitafloxacin anhydrous,DU-6859,DU6859A,DU-6859A
	Sitafloxacin, a new generation of broad-spectrum oral fluoroquinolones, is highly effective against many Gram-positive, Gram-negative, and anaerobic clinical isolates (including strains resistant to other fluoroquinolone...
T7999	7-Hydroxyflavanone		Anti-infection
	7-Hydroxyflavanone shows antimicrobial activity against Streptococcus pneumoniae clinical isolates.		Anti-infection
T5S1413	Nodakenetin	Prangeferol,(-)-Prangeferol,Nodakenitin	Others
	1. Nodakenetin ((-)-Prangeferol) has clinical efficacy.		Others
T4584	BMS-813160	BMS 813160	CCR
	BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.		CCR
T5479	AMG 333	AMG-333	TRP/TRPV Channel
	AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.		TRP/TRPV Channel
T27837	Linzagolix		GNRH Receptor
	Linzagolix is a small-molecule, non-peptide, orally active gonadotropin-releasing hormone antagonist (GnRH antagonist) which is under development by Kissei Pharmaceutical and ObsEva for the treatment of uterine fibroids,...		GNRH Receptor
T71691	Pumafentrine	BY 343	PDE
	Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.		PDE
T13925	THS-044	N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine,N-Morpholino-2-nitro-4-(trifluoromethyl)aniline	HIF
	THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity in endogenous and clinical settings.		HIF
T18929	Bromobimane	Monobromobimane	Autophagy
	Bromobimane (Monobromobimane) is a non-fluorescent substance, but reacts with thiols to produce a fluorescent product.Bromobimane is used as a probe, often in clinical medicine, to test for sulfide levels in blood.		Autophagy
T60098	MSC2504877	3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one	Others
	MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phos...		Others
T14130	Adomeglivant	LY2409021	Glucagon Receptor
	Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.		Glucagon Receptor
T7342	BM212		Antibacterial
	BM212 is an antimycobacterial compound.It inhibits the growth of laboratory and clinical isolate M. tuberculosis strains.		Antibacterial
TN7217	4,6-Benzilidine-D-Glucose
	4,6-Benzilidine-D-Glucose is a clinical antitumor compound showing antitumor activity in rats with chemically induced hepatocellular carcinoma.
T26520	ABP688	ABP-688,ABP 688	GluR
	ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.		GluR
T4977	Sofalcone	SU-88	Antibacterial , Autophagy
	Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.		Antibacterial , Autophagy
T7165	Basmisanil	RG1662,RO5186582	GABA Receptor
	Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndro...		GABA Receptor
T7221	Satraplatin	BMS182751,JM216,BMY45594	DNA Alkylator/Crosslinker , DNA Alkylation
	Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.		DNA Alkylator/Crosslinker , DNA Alkylation
T2764	(S)-10-Hydroxycamptothecin	10-Hydroxycamptothecin,10-HCPT	Apoptosis , Topoisomerase
	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.		Apoptosis , Topoisomerase