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(S)-10-Hydroxycamptothecin

Catalog No. T2764 CAS 19685-09-7

Synonyms: 10-Hydroxycamptothecin, 10-HCPT

(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

(S)-10-Hydroxycamptothecin Chemical Structure

(S)-10-Hydroxycamptothecin, CAS 19685-09-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 44.00
50 mg	In stock	$ 60.00
100 mg	In stock	$ 84.00
500 mg	In stock	$ 196.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.48%

Purity: 99.09%

Biological Description

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Storage & Solubility Information

Description	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
In vitro	In the CAM model, 10-Hydroxycamptothecin (25 nM) inhibits angiogenesis in a concentration-dependent manner. In mice carrying Colo 205 xenografts, oral administration of 10-Hydroxycamptothecin (2.5-7.5 mg/kg) every two days significantly suppresses tumor cell growth.
In vivo	(S)-10-Hydroxycamptothecin inhibits cell growth in BT-20 cells (IC50=34.3 nM) and MDA-231 cells (IC50=7.27 nM), demonstrating its efficacy. It also induces the formation of cleavable complexes mediated by human topoisomerase I in pBR322 plasmid DNA (EC50=0.35 μM). Additionally, in human microvascular endothelial cells (HMEC), (S)-10-Hydroxycamptothecin dose-dependently inhibits cell growth (IC50=0.31 μM), significantly hampers HMEC migration (IC50=0.63 μM), and impedes angiogenesis (IC50=0.96 μM).
Cell Research	Cells are exposed to various concentrations of 10-Hydroxycamptothecin for 72 hours. Cell growth is monitored by the standard MTT assay.(Only for Reference)
Source	Natural Products > Nyssaceae > Camptotheca

Synonyms	10-Hydroxycamptothecin, 10-HCPT
Molecular Weight	364.35
Formula	C20H16N2O5
CAS No.	19685-09-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8 mg/mL (21.95 mM), Heating is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Ling YH, et al. Cancer Biochem Biophys, 1990, 11(1), 23-30. 2. Vladu B, et al. Mol Pharmacol, 2000, 57(2), 243-251. 3. Xiao D, et al. Life Sci, 2001, 69(14), 1619-1628. 4. Ping YH, et al. Oncol Rep, 2006, 15(5), 1273-1279.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Inhibitor Library Anti-Aging Compound Library RO5 Drug-like Natural Product Library NO PAINS Compound Library Anti-Colorectal Cancer Compound Library Human Metabolite Library

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Keywords

(S)-10-Hydroxycamptothecin 19685-09-7 Apoptosis DNA Damage/DNA Repair Topoisomerase c-Myc Bcl-2 caspase-1/3r p53 Cell-cycle antitumor Bax (S)10Hydroxycamptothecin 10-Hydroxycamptothecin arrest PCNA G2/M 10-HCPT (S) 10 Hydroxycamptothecin inhibitor inhibit

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