antihyperglycemic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T26712	AZD-1656	AZD 1656	Glucokinase
	AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2 diabetes.		Glucokinase
T0247	Acarbose	BAY g 5421	Glucosidase
	Acarbose (BAY g 5421) is an inhibitor of α-Glucosidases with antihyperglycemic activity.		Glucosidase
T3675	1-Deoxynojirimycin	Duvoglustat,Moranoline,moranolin	PI3K , Glucosidase
	1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.		PI3K , Glucosidase
T0334	Rosiglitazone	BRL49653	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T1502	Vildagliptin	NVP-LAF 237,LAF237	Apoptosis , Ferroptosis , Proteasome , DPP-4
	Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolit...		Apoptosis , Ferroptosis , Proteasome , DPP-4
T21344	1-Deoxynojirimycin hydrochloride	Moranoline,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin	PI3K , Antibacterial , Antibiotic , Glucosidase
	1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia.		PI3K , Antibacterial , Antibiotic , Glucosidase
T6646	Rosiglitazone hydrochloride	BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
TN1026	Vomicine		Others
	Vomicine is a natural product from Strychnos nux-vomica, the S. nux-vomica extracts show antihyperglycemic activity in experimental animals.		Others
T1529	Miglitol	BAY1099,BAY-m1099	Others
	Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity.		Others
T1453	Phenformin hydrochloride	Phenformin HCl,Phenethylbiguanide hydrochloride	Potassium Channel , AMPK , Autophagy
	Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.		Potassium Channel , AMPK , Autophagy
T8493	Ingliforib	GPi 296,CP 368296	Phosphorylase
	Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor,has antihyperglycemic and cardioprotective properties.		Phosphorylase
T5743	Gymnemagenin		Liver X Receptor
	Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.		Liver X Receptor
T6S1371	Isovitexin	Homovitexin,Saponaretin,Apigenin-6-C-Glucoside	NF-κB , JNK , Glucosidase
	1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.		NF-κB , JNK , Glucosidase
T7846	Aegeline		Others , Antifungal
	Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.		Others , Antifungal
T21764	MCC-555	Isaglitazone,Netoglitazone	PPAR
	MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.		PPAR
T3547	Sotagliflozin	LX-4211,LP-802034	SGLT
	Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.		SGLT
T7448	4-Hydroxyisoleucine	4-Hydroxy-L-isoleucine	Others
	4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) has antidepressant-like, antidyslipidemic, and antihyperglycemic effects. It displays an insulinotropic activity.		Others
T1527	Gliclazide	S1702,SE1702	Potassium Channel
	Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to release insulin.		Potassium Channel
T2389	Dapagliflozin	BMS-512148	SGLT , HIF
	Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.		SGLT , HIF
TN2247	Swertisin		Adenosine Receptor
	Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic, anti-inflammatory and antioxidant effects.		Adenosine Receptor