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Dapagliflozin

Catalog No. T2389 CAS 461432-26-8

Synonyms: BMS-512148

Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.

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Dapagliflozin, CAS 461432-26-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 42.00
10 mg	In stock	$ 58.00
25 mg	In stock	$ 74.00
50 mg	In stock	$ 91.00
100 mg	In stock	$ 115.00
200 mg	In stock	$ 153.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.74%

Purity: 99.5%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.
Targets&IC50	SGLT2 (human):1.1 nM(EC50)
Cell Research	To perform the cell survival assay, cells are collected after 24 h incubation with vehicle or dapagliflozin pretreatment in 30-min ischemia and surviving cells are counted with Trypan blue staining. The percentage survival is determined by quantization of the relative viable number of treated cells divided by the viable number of untreated cells.

Synonyms	BMS-512148
Molecular Weight	408.87
Formula	C21H25ClO6
CAS No.	461432-26-8

Storage

store at low temperature,store under nitrogen,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 14 mg/mL (34.2 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 76 mg/mL (185.9 mM)

References and Literature

1. Meng W, et al. J Med Chem, 2008, 51(5), 1145-1149. 2. Han S, et al. Diabetes, 2008, 57(6), 1723-1729. 3. Obermeier M, et al. Drug Metab Dispos, 2010, 38(3), 405-414. 4. Macdonald FR, et al. Diabetes Obes Metab, 2010, 12(11), 12004-12012. 5. Chiba Y, et al. Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice. PLoS One. 2016 Mar 10;11(3):e0150756.

Citations

1. Xuan M Y, Piao S G, Ding J, et al. Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction. Frontiers in pharmacology. 2021, 12 2. Ding L, Chen X, Zhang W, et al.Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling.The Journal of Clinical Investigation.2023, 133(1). 3. Huang H, Kung F L, Huang Y W, et al.Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin.Biochemical Pharmacology.2024: 116140.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Highly Selective Inhibitor Library Inhibitor Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library GPCR Compound Library Anti-Cancer Approved Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

Sotagliflozin SGLT inhibitor-1 Phlorizin Ertugliflozin Picraline Sergliflozin A LY2794193 Sergliflozin etabonate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dapagliflozin 461432-26-8 Angiogenesis Chromatin/Epigenetic GPCR/G Protein SGLT HIF BMS512148 Sodium-dependent glucose cotransporters inhibit BMS-512148 BMS 512148 Inhibitor inhibitor

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