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Aegeline

Catalog No. T7846 CAS 456-12-2

Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.

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Aegeline, CAS 456-12-2

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500 mg	In stock	$ 39.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.98%

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Description	Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.
In vitro	Aegeline enhanced GLUT4 translocation mediated 2-deoxy-glucose uptake in both time and concentration-dependent manner.?2-deoxy-glucose uptake was completely stymied by the transport inhibitors (wortmannin and genistein) in C2C12 myotubes.?Pharmacological inhibition of Akt (also known as protein kinase B) and Ras-related C3 botulinum toxin substrate 1 (Rac1) suggest that both Akt and Rac1 operate aegeline-stimulated glucose transport via distinct parallel pathways.?Moreover, aegeline activates p21 protein-activated kinase 1 (PAK1) and cofilin (an actin polymerization regulator).?Rac1 inhibitor (Rac1 inhib II) and PAK1 inhibitor (IPA-3) completely blocked aegeline-induced phosphorylation of cofilin and p21 protein-activated kinase 1 (PAK1)[1].
Source	Natural Products > Cannabaceae > Cannabis

Molecular Weight	297.35
Formula	C18H19NO3
CAS No.	456-12-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (84.07 mM)

References and Literature

1. Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1[J]. European Journal of Pharmacology, 2015, 762:419-429. 2. Nugroho A E , Riyanto S , Sukari M A , et al. EFFECTS OF AEGELINE, A MAIN ALKALOID OF AEGLE MARMELOS CORREA LEAVES, ON THE HISTAMINE RELEASE FROM MAST CELLS[J]. Pakistan Journal of Pharmaceutical Sciences, 2011, 24(24):359-367.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Natural Product Library Anti-Diabetic Compound Library Bioactive Compounds Library Max Bioactive Compound Library RO5 Drug-like Natural Product Library Selected Plant-Sourced Compound Library Covalent Natural Product Library Anti-Infection Compound Library Covalent Inhibitor Library

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Keywords

Aegeline 456-12-2 Microbiology/Virology Others Antifungal αsyn yeast Inhibitor protein Sec22p inhibit toxicity Fungal SNARE inhibitor

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